Vancomin 500 mg/vial (IV Infusion)

500 mg vial: ৳ 250.94

Medicine Details

Category Details
Generic Vancomycin hydrochloride
Company Opsonin pharma ltd
Also available as
Vancomin 1 gm injection Vancomin 250 mg capsule

Title

  • Vancomycin Hydrochloride Injection

Categories

  • Antibiotic
  • Medication

Description

  • Potentially life-threatening infections treatment
  • Severe staphylococcal infections therapy
  • Endocarditis treatment and prophylaxis
  • Infections due to staphylococci treatment
  • Cell wall synthesis inhibition
  • Dosage in adults and children
  • Dosage adjustment for impaired renal function
  • Capsule dosage for antibiotic-associated pseudomembranous colitis
  • Contraindicated in hypersensitivity to Vancomycin
  • Anaphylactic reactions during rapid infusion
  • Pregnancy and lactation precautions
  • Serial auditory function tests for patients over 60
  • Injection site necrosis and irritation
  • Overgrowth of non-susceptible organisms caution
  • Limited benefit of haemoperfusion with Amberlite resin XAD-4
  • Storage in cool, dry place protected from light

DosageAndAdministration

  • Concentrations of no more than 5 mg/ml
  • Rates of no more than 10 mg/min
  • Usual daily dose for adults: 2 gm (in 4 or 2 divided doses)
  • Total daily dose for children: 40 mg/Kg (in 4 divided doses)
  • Initial dose for infants and neonates: 15 mg/Kg
  • Dosage adjustment for impaired renal function
  • Capsule dosage for adults with antibiotic-associated pseudomembranous colitis: 125 to 500 mg administered orally every 6 to 8 hours for 7 to 10 days
  • Capsule dosage for pediatrics: approximately 40 mg/kg in 3 or 4 divided doses for 7 to 10 days administered orally

Pharmacology

  • Binding to D-alanyl-D-alanine portion cell wall precursor
  • Blockage of glycopeptide polymerisation
  • Immediate inhibition of cell wall synthesis
  • Secondary damage to the cytoplasmic membrane

Contraindications

  • Known hypersensitivity to Vancomycin

SideEffects

  • Anaphylactic reactions
  • Hypotension
  • Wheezing
  • Dyspnoea
  • Urticaria
  • Pruritus
  • Flushing of the upper body
  • Pain and muscle spasm of the chest and back
  • Injection site pain
  • Thrombophlebitis

PregnancyAndLactation

  • Potential foetal harm
  • Excretion in human milk

PrecautionsAndWarnings

  • Borderline renal function caution
  • Serial tests of auditory function
  • Periodic haematological studies
  • Injection site necrosis caution
  • Pseudomembranous colitis caution

OverdoseEffects

  • Supportive care advised
  • Poor removal from the blood by haemodialysis or peritoneal dialysis
  • Limited benefit of haemoperfusion with Amberlite resin XAD-4

TherapeuticClass

  • Other antibiotic

StorageConditions

  • Cool and dry place
  • Protected from light
  • Keep out of reach of children

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