Vancomin 1 gm/vial (IV Infusion)

1 gm vial: ৳ 483.25

Medicine Details

Category Details
Generic Vancomycin hydrochloride
Company Opsonin pharma ltd
Also available as
Vancomin 500 mg injection Vancomin 250 mg capsule

Indications

  • Treatment of potentially life-threatening infections
  • Useful in severe staphylococcal infections
  • Therapy for endocarditis
  • Prophylaxis against endocarditis
  • Treatment of infections including osteomyelitis, pneumonia, septicemia, and soft tissue infections

Pharmacology

  • Binds tightly to D-alanyl-D-alanine portion cell wall precursor
  • Causes blockage of glycopeptide polymerization
  • Inhibition of cell wall synthesis
  • Secondary damage to the cytoplasmic membrane

Dosage & Administration

  • Recommended concentrations and rates for adults
  • Dosage for patients with normal renal function
  • Dosage for patients with impaired renal function and elderly patients
  • Recommended dosage adjustments
  • Recommended method of administration

Contraindications

  • Hypersensitivity to Vancomycin

Side Effects

  • Anaphylactic reactions
  • Hypotension
  • Wheezing
  • Dyspnoea
  • Urticaria
  • Pruritus
  • Flushed upper body
  • Pain and muscle spasm of the chest and back
  • Reaction resolution timeframe
  • Infusion method impact on reactions frequency

Pregnancy & Lactation

  • Unknown impact on fetal harm
  • Caution in pregnancy
  • Careful monitoring of blood levels
  • Excretion in human milk
  • Caution in nursing women
  • Unlikelihood of significant absorption by nursing infants

Precautions & Warnings

  • Serial tests for auditory function and blood levels for specific demographics
  • Periodic hematological studies
  • Urine analysis
  • Irritation to tissue
  • Injection site necrosis
  • Necessity of intravenous infusion
  • Injection site pain and thrombophlebitis prevalence
  • Possible overgrowth of non-susceptible organisms
  • Observation and superinfection measures
  • Reports of pseudomembranous colitis in rare instances

Overdose Effects

  • Supportive care advised
  • Maintenance of glomerular filtration
  • Poor removal from blood by haemodialysis or peritoneal dialysis
  • Limited benefit of haemoperfusion with Amberlite resin XAD-4

Therapeutic Class

  • Other antibiotic

Storage Conditions

  • Cool and dry storage
  • Protected from light
  • Keep out of reach of children

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