Vanmycin 500 mg/vial (IV Infusion)
500 mg vial: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Vancomycin hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of potentially life-threatening infections
- Therapy for severe staphylococcal infections
- Treatment of endocarditis
- Prophylaxis against endocarditis
- Treatment of infections due to staphylococci such as osteomyelitis, pneumonia, septicemia, and soft tissue infections
Pharmacology
- Binds tightly to D-alanyl-D-alanine portion cell wall precursor
- Causes blockage of glycopeptide polymerisation
- Inhibits cell wall synthesis
- Causes secondary damage to the cytoplasmic membrane
Dosage & Administration
- Recommended concentrations and rates for adults
- Dosage for patients with normal renal function
- Dosage for patients with impaired renal function and elderly patients
- Recommended dosage adjustments based on creatinine clearance
- Administration for adults and pediatrics
- Capsule dosage for adults and pediatrics
Contraindications
- Contraindicated in patients with known hypersensitivity to Vancomycin
Side Effects
- Potential anaphylactic reactions
- Hypotension
- Wheezing
- Dyspnoea
- Urticaria
- Pruritus
- Rapid infusion effects such as flushing, pain, and muscle spasm
- Tolerance of slow infusion
Pregnancy & Lactation
- Unknown impact on fetal health
- Recommendation for cautious use during pregnancy
- Excretion in human milk
- Caution in administration to nursing women
- Unlikely significant absorption by nursing infants
Precautions & Warnings
- Serial tests for auditory function and Vancomycin blood levels for patients with borderline renal function and individuals over 60
- Periodic hematological studies, urine analysis, and renal function tests for all patients
- Irritating to tissue
- Injection site necrosis when administered intramuscularly
- Requirement for intravenous infusion
- Potential injection site pain and thrombophlebitis
- Possibility of overgrowth of non-susceptible organisms with prolonged use
- Necessity for careful observation and management of superinfection
- Risk of pseudomembranous colitis due to C. difficile in rare instances
Overdose Effects
- Supportive care advised
- Maintenance of glomerular filtration
- Low removal from blood by hemodialysis and peritoneal dialysis
- Limited benefit of haemoperfusion with Amberlite resin XAD-4
Therapeutic Class
- Other antibiotic
Storage Conditions
- Cool and dry storage
- Protection from light
- Keep out of reach of children