Targocid 200 mg/vial (IM/IV Injection)

Title

• Targocid Antibiotic Medicine

Categories

• Medicine
• Healthcare
• Pharmaceutical

Description

• Glycopeptide-antibiotic for treating various infections
• Produced by Actinoplanes teichomyceticus
• Sterile, pyrogen-free ivory white powder for reconstitution with water for injection
• Freely soluble in water and gives a clear solution on reconstitution
• Inhibits cell-wall biosynthesis of susceptible organisms
• Interferes with peptidoglycan synthesis
• Can be given intravenously or intramuscularly
• Dosage should be adapted based on infection severity and patient's response
• Contraindicated in patients with known hypersensitivity to the drug
• May cause local (erythema, injection site abscess), allergic (rash, pruritus), gastrointestinal (nausea, vomiting), CNS (weakness, dizziness) and hearing (ringing in ears) reactions
• Pregnancy Category B3 - should be used with caution during pregnancy and lactation
• Should be administered with caution in patients known to be hypersensitive to Vancomycin
• Belongs to therapeutic class - Glycopeptide
• Requires reconstitution with water before administration

Indications

• Complicated skin and soft tissue infections
• Bone and joint infections
• Hospital-acquired pneumonia
• Community-acquired pneumonia
• Complicated urinary tract infections
• Infective endocarditis
• Alternative oral treatment for Clostridium difficile infection-associated diarrhoea and colitis

Mode of Action

• Interferes with cell-wall biosynthesis at a site different from beta-lactams
• Specific binding to D-alanyl-D-alanine residues

Dosage & Administration

• Given intravenously (bolus injection or infusion) or intramuscularly
• Dosage adjusted based on infection severity and patient's kidney function
• Appropriate for adults, elderly, and children with normal or kidney failure
• Recommended dosage for various infections and age groups

Interaction

• Administered with caution in patients receiving concurrent nephrotoxic or ototoxic drugs

Contraindications

• Contraindicated in patients with known Hypersensitivity to the drug

Side Effects

• Local reaction: erythema, injection site abscess when given intramuscularly
• Allergic reaction: rash, pruritus, fever, shivering, anaphylactic reactions
• Gastrointestinal reactions: nausea, vomiting, diarrhea
• CNS reactions: physical weakness, dizziness, headache
• Hearing reactions: ringing in the ears, balance disorders

Pregnancy & Lactation

• Pregnancy Category B3 - should not be used during pregnancy or lactation unless benefits outweigh risks

Precautions & Warnings

• Administered with caution in patients known to be hypersensitive to Vancomycin

Therapeutic Class

• Glycopeptide

Reconstitution

• Inject slowly the water into the powder vial containing active ingredient
• Rotate the vial gently until all the powder is dissolved
• Use specific infusion solutions for administration

Storage Conditions

• Store at a temperature not exceeding 30°C in a dry place
• Reconstituted solution should be used immediately or stored under refrigeration for 24 hours maximum

Related Brands