Sytrim (200 mg+40 mg)/5 ml (Oral Suspension)

Brand Name

Cotrimoxazole

Category

Medicine

Dosage Form

Tablet, Suspension

Strength

Double Strength

Indications

• Respiratory tract infections
• Genito-urinary tract infections
• Gastro-intestinal tract infections
• Osteomyelitis
• Brucellosis
• Skin infections
• Septicaemia
• Bacillary dysentery

Mode of Action

Bactericidal activity against a wide range of bacteria and some protozoa

Dosage and Administration

• Different dosages for mild, moderate, and severe infections
• Long-term therapy guidelines
• Dosages for specific conditions like gonorrhoea

Contraindications

• Hypersensitivity to trimethoprim or sulphonamides
• Megaloblastic anaemia due to folate deficiency
• Liver parenchymal damage
• Blood dyscrasia
• Severe renal insufficiency
• Glucose 6-phosphate dehydrogenase deficiency

Side Effects

• Crystalluria
• Allergic reactions
• Haemolysis
• Thrombocytopenia
• Neutropenia
• Agranulocytosis
• Malaise
• Headache
• Nausea
• Vomiting

Pregnancy and Lactation

Excretion in breast milk may cause kernicterus

Precautions and Warnings

• Risk of macrocytic anaemia
• Interference with the conversion of Folic acid into Folinic acid
• Possible potentiation of action of sulphonylurea in diabetic patients

Therapeutic Class

Anti-diarrhoeal Antimicrobial drugs, Sulphonamides & Trimethoprim

Storage Conditions

Keep below 30°C, away from light & moisture, out of the reach of children