Tyclav (125 mg+31.25 mg)/5 ml (Powder for Suspension)

100 ml bottle: ৳ 220.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Beximco pharmaceuticals ltd
Also available as
Tyclav 500 mg injection Tyclav 1 gm injection Tyclav 875 mg tablet Tyclav 250 mg tablet Tyclav 500 mg tablet Tyclav bid 400 mg suspension

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Genito-urinary tract infections
  • Skin and soft tissue infections
  • Bone and joint infections
  • Other infections

Composition

  • 375 mg tablet: Amoxicillin 250 mg, Clavulanic Acid 125 mg
  • 625 mg tablet: Amoxicillin 500 mg, Clavulanic Acid 125 mg
  • 1 gm tablet: Amoxicillin 875 mg, Clavulanic Acid 125 mg
  • Powder for Suspension: Amoxicillin 125 mg, Clavulanic Acid 31.25 mg
  • Powder for Suspension (Forte): Amoxicillin 400 mg, Clavulanic Acid 57.5 mg
  • 1.2 gm Injection: Amoxicillin 1 gm, Clavulanate Potassium 200 mg
  • 0.6 gm injection: Amoxicillin 500 mg, Clavulanate Potassium 100 mg

Pharmacology

Combination of Amoxicillin and Clavulanic Acid with broad bactericidal activity

Dosage

  • Adults and children over 12 years dosage guidelines
  • Children of 2 to 12 years dosage guidelines
  • IV Injection dosage guidelines

Administration

Oral intake without regard to meals, IV injection protocol

Interaction

  • Prolongation of bleeding time and prothrombin time
  • Reduced efficacy of oral contraceptives
  • Concomitant use of allopurinol
  • No data on concomitant use of Co-amoxiclav and allopurinol

Contraindications

  • Penicillin hypersensitivity
  • Cross-sensitivity with other beta-lactam antibiotics
  • History of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

  • Diarrhoea
  • Pseudomembranous colitis
  • Indigestion
  • Hepatitis
  • Cholestatic jaundice
  • Urticarial and erythematous rashes
  • Angioedema
  • Anaphylaxis

Pregnancy & Lactation

Animal studies show no teratogenic effects, limited use in human pregnancy, trace quantities in breast milk

Precautions & Warnings

  • Use with care in patients on anticoagulation therapy
  • Dosage adjustment for renal impairment
  • Maintenance of fluid intake and urinary output

Use in Special Populations

Dosage adjustment for renal and hepatic impairment

Overdose Effects

Unlikely, with potential gastrointestinal symptoms

Therapeutic Class

Broad spectrum penicillins

Reconstitution

IV injection reconstitution guidelines

Storage Conditions

  • Below 25°C, protected from light and moisture
  • Refrigeration of reconstituted suspension
  • Time limits for reconstituted vial

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