Quinox DS 250 mg/5 ml (Powder for Suspension)

Therapeutic Class

• 4-Quinolone preparations
• Anti-diarrhoeal
• Antimicrobial drugs

Indications

• Treatment of single infection or mixed infections
• Infections caused by susceptible organisms
• Urinary, respiratory, and gastrointestinal tract infections
• Gonorrhea, septicaemia, skin and soft tissue infections
• Gastro-intestinal, biliary tract, intra abdominal, bone and joint infections
• Eye, ear, nose, and throat infections
• Pelvic infections

Pharmacology

• Synthetic quinolone anti-infective agent
• Broad spectrum of activity against gram-negative and gram-positive aerobic bacteria
• Bactericidal action results from interference with DNA gyrase

Dosage

• Dosage range for adults is 100-750 mg twice daily
• Different dosage for urinary tract, respiratory tract, and gonorrhea infections
• Adjustment for impaired renal function and elderly patients
• Duration of treatment depends upon severity of infection and clinical response

Administration

• Instruction for IV infusion
• Proper fluid level establishment during infusion
• Regulation of rate of administration with flow control clamp

Interaction

• Avoid concurrent administration with Magnesium or Aluminum containing antacids or sucralfate
• Avoid concurrent use with products containing Calcium, Iron, or Zinc
• Should not be taken concurrently with milk or other dairy products

Contraindications

• Hypersensitivity to Ciprofloxacin or other quinolones

Side Effects

• Gastrointestinal disturbances
• Disturbances of the central nervous system
• Hypersensitivity reactions
• Joint pain, mild photosensitivity
• Transient increase in liver enzymes
• Risk of hypoglycemia & mental health adverse effects

Pregnancy & Lactation

• Not recommended during pregnancy due to arthropathy in immature animals
• Secreted in milk, not recommended for nursing mothers

Precautions & Warnings

• Use with caution in patients with suspected or known CNS disorders
• Drink fluids liberally
• Avoid concurrent administration with magnesium / aluminium antacids
• Should not be taken concurrently with milk or yogurt alone

Use in Special Populations

• Not a drug of first choice in pediatric population

Overdose Effects

• May lead to seizures, hallucinations, confusion, abdominal discomfort
• Renal and hepatic impairment
• Crystalluria, haematuria, reversible renal toxicity

Storage Conditions

• Keep below 30°C temperature
• Protected from light & moisture
• Keep out of the reach of children

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