Amiquin 400 mg (Tablet)

Indications

• Acute bacterial exacerbation of chronic bronchitis
• Acute sinusitis
• Community-acquired pneumonia
• Uncomplicated skin and skin structure infections
• Uncomplicated urinary tract infections
• Complicated urinary tract infections
• Pyelonephritis
• Uncomplicated urethral and cervical gonorrhea
• Acute, uncomplicated rectal infections in women

Pharmacology

Inhibits DNA synthesis in susceptible organisms

Dosage

• Acute Bacterial Exacerbation of Chronic Bronchitis: 400 mg for 5 days
• Acute Sinusitis: 400 mg for 10 days
• Community-acquired Pneumonia: 400 mg for 7-14 days
• Uncomplicated Skin and Skin Structure Infections: 400 mg for 7-10 days
• Uncomplicated Urinary Tract Infections: 400 mg single dose or 200 mg for 3 days
• Complicated Urinary Tract Infections: 400 mg for 7-10 days
• Acute Pyelonephritis: 400 mg for 7-10 days
• Uncomplicated Urethral Gonorrhea in Men: 400 mg as a single dose

Administration

Can be administered without regard to food

Contraindications

Hypersensitivity to gatifloxacin or any quinolone antimicrobial agents

Side Effects

• Nausea
• Vomiting
• Stomach pain
• Diarrhea
• Dizziness
• Headache

Pregnancy & Lactation

• Pregnancy: Use only if potential benefit outweighs potential risk to the fetus
• Lactation: Caution when administered to a nursing woman

Precautions & Warnings

Administered with caution in the presence of renal insufficiency

Use in Special Populations

• Renal Impaired Patient:
  • Creatinine Clearance 40 mL/min: 400 mg daily
  • Creatinine Clearance < 40 mL/min: 400 mg 200 mg daily
• Dialysis Patients:
  • Hemodialysis: 400 mg 200 mg daily
  • Continuous peritoneal dialysis: 400 mg 200 mg daily
• Pediatric Use: Safety and effectiveness not established in pediatric populations

Overdose Effects

Low potential for acute toxicity, symptomatic and supportive treatment recommended

Therapeutic Class

4-Quinolone preparations

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