Acmecilin 125 mg/5 ml (Oral Suspension)

Indications

• Treatment of infections of the Genitourinary Tract including Gonorrhea
• Treatment of infections of the Respiratory Tract
• Treatment of infections of the Gastrointestinal Tract
• Treatment of Meningitis

Pharmacology

• Inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins
• Lysis of bacteria due to activity of cell wall autolytic enzymes

Dosage

• Intra-articular dosage for adults and children
• Intraperitoneal dosage for adults and children
• Intrapleural dosage for adults and children
• Intravenous dosage for Meningitis in adults and children
• Oral dosage for various infections in adults and children
• Parenteral dosage for susceptible infections in adults and children
• Dosage for septicaemia in adults and children

Administration

Take on an empty stomach, 1 hr before or 2 hr after meals

Interaction

• May reduce efficacy of oral contraceptives
• May alter INR while on warfarin and phenindione
• May reduce efficacy of oral typhoid vaccines
• May reduce excretion of methotrexate
• Reduced excretion with probenecid and sulfinpyrazone
• Increased risk of toxicity with probenecid and sulfinpyrazone
• Increased skin reactions with allopurinol
• Reduced absorption with chloroquine
• Interference with bactericidal action by bacteriostatic antibacterials

Contraindications

Hypersensitivity to ampicillin and other penicillins

Side Effects

• Nausea
• Vomiting
• Diarrhoea
• Rashes
• Sore mouth
• Skin reactions
• Fever
• Joint pains
• Haemolytic anaemia
• CNS toxicity
• Nephropathy
• Hepatitis
• Jaundice
• Increase in transaminases
• Anaphylaxis
• Clostridium difficile-associated diarrhoea

Pregnancy & Lactation

Pregnancy Category B

Precautions & Warnings

For patients with history of β-lactam allergy, during renal impairment, pregnancy, and lactation

Use in Special Populations

Dose adjustment for patients with renal impairment

Overdose Effects

• Symptoms: Nausea, vomiting, diarrhoea
• Management: Symptomatic and supportive treatment, may be removed from circulation by hemodialysis

Reconstitution

• Intramuscular reconstitution
• Intravenous reconstitution
• Intra-articular reconstitution
• Intraperitoneal reconstitution
• Intrapleural reconstitution

Storage Conditions

Store between 20-25°C, reconstituted oral suspension to be stored between 2-8°C and discarded after 14 days

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