GQ-400 400 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Gatifloxacin |
| Company | Ultra Pharma Ltd. |
Indications
- Acute bacterial exacerbation of chronic bronchitis
- Acute sinusitis
- Community-acquired pneumonia
- Uncomplicated skin and skin structure infections
- Uncomplicated urinary tract infections
- Complicated urinary tract infections
- Pyelonephritis
- Uncomplicated urethral and cervical gonorrhea
- Acute, uncomplicated rectal infections in women
Pharmacology
Inhibits DNA synthesis in susceptible organisms via inhibition of both DNA gyrase and topoisomerase IV
Dosage
- 400 mg for acute bacterial exacerbation of chronic bronchitis for 5 days
- 400 mg for acute sinusitis for 10 days
- 400 mg for community-acquired pneumonia for 7-14 days
- 400 mg for uncomplicated skin and skin structure infections for 7-10 days
- 400 mg single dose or 200 mg for uncomplicated urinary tract infections for 3 days
- 400 mg for complicated urinary tract infections for 7-10 days
- 400 mg for acute pyelonephritis for 7-10 days
- 400 mg single dose for uncomplicated urethral gonorrhea in men
Administration
Can be administered without regard to food
Contraindications
Not to be used in patients with a history of hypersensitivity to Gatifloxacin or quinolone antimicrobial agents
Side Effects
- Nausea
- Vomiting
- Stomach pain
- Diarrhea
- Dizziness
- Headache
Pregnancy & Lactation
Should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Caution should be exercised when administered to a nursing woman
Precautions & Warnings
Should be administered with caution in the presence of renal insufficiency
Use in Special Populations
- Renal Impaired patient:
- Creatinine Clearance 40 mL/min: 400 mg every day
- Creatinine Clearance < 40 mL/min: 400 mg 200 mg every day
- Dialysis patients:
- Hemodialysis: 400 mg 200 mg every day
- Continuous peritoneal dialysis: 400 mg 200 mg every day
- Pediatric use: The safety and effectiveness in pediatric populations (<18 years of age) have not been established
Overdose Effects
Exhibits a low potential for acute toxicity. In the event of acute oral overdose, the stomach should be emptied by inducing vomiting or by gastric lavage. The patient should be carefully observed (including ECG monitoring) and given symptomatic and supportive treatment. Adequate hydration should be maintained
Therapeutic Class
4-Quinolone preparations