Ampexin 500 mg/vial (Injection)
500 mg vial: ৳ 24.00 (1 x 4: ৳ 96.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ampicillin sodium |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of infections in genitourinary tract
- Treatment of infections in respiratory tract
- Treatment of infections in gastrointestinal tract
- Treatment of meningitis
- Bacteriology studies to determine causative organisms
- Therapy prior to results of susceptibility testing
Pharmacology
- Inhibition of bacterial cell wall synthesis
- Binding to penicillin-binding proteins
- Inhibition of transpeptidation step
- Lysis of bacteria
- Inactivation of cell wall autolytic enzymes
Dosage
- Dosage for intra-articular use in adults
- Dosage for intra-articular use in children
- Dosage for intraperitoneal use in adults
- Dosage for intraperitoneal use in children
- Dosage for intrapleural use in adults
- Dosage for intrapleural use in children
- Dosage for intravenous use in adults for meningitis
- Dosage for intravenous use in children for meningitis
- Dosage for intrapartum prophylaxis in adults
- Dosage for oral use in various infections
- Dosage for typhoid and paratyphoid fever in adults
- Dosage for uncomplicated gonorrhoea in adults
- Dosage for urinary tract infections in adults
- Dosage for parenteral use in adults
- Dosage for parenteral use in children
- Dosage for septicaemia in adults
- Dosage for septicaemia in children
Administration
Should be taken on an empty stomach
Interaction
- Reduction of efficacy of oral contraceptives
- Alteration of INR while on warfarin and phenindione
- Reduction of efficacy of oral typhoid vaccines
- Reduced excretion with probenecid and sulfinpyrazone
- Increased risk of toxicity with probenecid and sulfinpyrazone
- Increased ampicillin-induced skin reactions with allopurinol
- Reduced absorption with chloroquine
- Interference with bactericidal action by bacteriostatic antibacterials
Contraindications
Hypersensitivity to ampicillin and other penicillins
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Rashes
- Sore mouth
- Black/hairy tongue
- Skin reactions
- Systemic symptoms
- Haematological disorders
- Coagulation disorders
- CNS toxicity
- Renal disorders
- Hepatic disorders
- Anaphylaxis
- Clostridium difficile-associated diarrhoea
Pregnancy & Lactation
Category B: No fetal risk demonstrated in animals
Precautions & Warnings
- History of β-lactam allergy
- Renal impairment
- Pregnancy
- Lactation
Use in Special Populations
Dose adjustment for renal impairment
Overdose Effects
- Symptoms of nausea, vomiting, and diarrhoea
- Symptomatic and supportive treatment
- Potential removal by haemodialysis
Reconstitution
- Intramuscular: Addition of water for injection to vial contents
- Intravenous: Dissolution in water for injection or infusion fluids
- Intra-articular: Dissolution in water for injection or sterile procaine HCl solution
- Intraperitoneal: Dissolution in water for injection
- Intrapleural: Dissolution in water for injection
Storage Conditions
Store between 20-25°C. Reconstituted oral suspension to be stored between 2-8°C and discarded after 14 days
Related Brands
- Skycillin 250 mg (Capsule) - skylab-pharmaceuticals-ltd
- Seemacillin 125 mg/1.25 ml (Pediatric Drops) - seema-pharmaceuticals-ltd
- Seemacillin 125 mg/5 ml (Oral Suspension) - seema-pharmaceuticals-ltd
- Ampirex 500 mg/vial (IM/IV Injection) - jayson-pharmaceuticals-ltd
- Ampimet DS 125 mg/5 ml (Oral Suspension) - medimet-pharmaceuticals-ltd