Ampimet 250 mg (Capsule)

Unit Price: ৳ 3.25 (100's pack: ৳ 325.00)

Medicine Details

Category Details
Generic Ampicillin sodium
Company Medimet pharmaceuticals ltd
Also available as
Ampimet 500 mg capsule Ampimet ds 125 mg suspension

Indications

  • Infections of the Genitourinary Tract Including Gonorrhea
  • Infections of the Respiratory Tract
  • Infections of the Gastrointestinal Tract
  • Meningitis

Categories

  • Antibiotic
  • Medication
  • Pharmaceutical

Dosage

  • Intra-articular
  • Intraperitoneal
  • Intrapleural
  • Intravenous
  • Oral
  • Parenteral
  • Septicaemia

RecommendedDosage

  • Intra-articular:
    • Adult: 500 mg daily
    • Child: Half of adult routine dosage
  • Intraperitoneal:
    • Adult: 500 mg daily
    • Child: Half of adult routine dosage
  • Intrapleural:
    • Adult: 500 mg daily
    • Child: Half of adult routine dosage
  • Intravenous:
    • Meningitis:
      • Adult: 2 gm 6 hrly
      • Child: 150 mg/kg daily in divided doses
    • Intrapartum prophylaxis against group B Streptoccocal infection in neonates: Initially, 2 gm via IV inj followed by 1 gm 4 hrly until delivery
  • Oral:
    • Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Otitis media, Perinatal streptococcal infections, Peritonitis:
      • Adult: 0.25-1 gm 6 hrly
      • Child: Half of adult routine dosage
    • Typhoid and paratyphoid fever: 1-2 gm 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers
    • Uncomplicated gonorrhoea: 2 gm with 1 gm of probenecid as single dose, recommended to be repeated in female patients
    • Urinary tract infections: 500 mg 8 hrly
  • Parenteral:
    • Adult: 500 mg 6 hrly, via IM or slow IV inj over 3-5 min or by infusion
    • Child: Half of adult routine dosage
  • Septicaemia:
    • Adult: 150-200 mg/kg daily. Initiate with IV admin for at least 3 days, then continue with IM inj 3-4 hrly
    • Child: Same as adult dose

Administration

Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals

Interaction

  • May reduce the efficacy of oral contraceptives
  • May alter INR while on warfarin and phenindione
  • May reduce the efficacy of oral typhoid vaccines
  • May reduce the excretion of methotrexate
  • Reduced excretion with probenecid and sulfinpyrazone, resulting to increased risk of toxicity
  • Allopurinol increases ampicillin-induced skin reactions
  • Reduced absorption with chloroquine
  • Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere with the bactericidal action of ampicillin

Contraindications

Hypersensitivity to ampicillin and other penicillins

SideEffects

  • Nausea
  • vomiting
  • diarrhoea
  • erythematous maculo-papular rashes
  • sore mouth
  • black/hairy tongue
  • rash
  • erythema multiforme
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • angioedema
  • fever
  • joint pains
  • serum sickness-like symptoms
  • haemolytic anaemia
  • thrombocytopenia
  • leucopenia
  • neutropenia
  • coagulation disorders
  • prolonged bleeding time and prothrombin time
  • CNS toxicity (e.g. convulsions)
  • paraesthesia
  • nephropathy
  • interstitial nephritis
  • hepatitis
  • cholestatic jaundice
  • moderate and transient increase in transaminases
  • Anaphylaxis
  • Clostridium difficile-associated diarrhoea (CDAD)

PregnancyAndLactation

Pregnancy Category B.

PrecautionsAndWarnings

  • Patient with history of β-lactam allergy
  • During renal impairment
  • Pregnancy and lactation

UseInSpecialPopulations

  • Renal Impairment: CrCl<10: Dose reduction or increase in dose interval

OverdoseEffects

  • Symptoms: Nausea, vomiting and diarrhoea
  • Management: Symptomatic and supportive treatment. May be removed from the circulation by haemodialysis

Reconstitution

  • Intramuscular: Add 1.5 mL water for inj to 500 mg vial contents
  • Intravenous: Dissolve 500 mg in 10 mL water for inj. May be added to infusion fluids or injected, suitably diluted into the drip tube
  • Intra-articular: Dissolve 500 mg in up to 5 mL of water for inj or sterile procaine HCl 0.5% soln
  • Intraperitoneal: Dissolve 500 mg in up to 10 mL water for inj
  • Intrapleural: Dissolve 500 mg in 5-10 mL water for inj

StorageConditions

Store between 20-25° C. Reconstituted oral susp: Store between 2-8° C (discard after 14 days)

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