Ampimet 250 mg (Capsule)
Unit Price: ৳ 3.25 (100's pack: ৳ 325.00)
Medicine Details
Category | Details |
---|---|
Generic | Ampicillin sodium |
Company | Medimet pharmaceuticals ltd |
Also available as |
Indications
- Infections of the Genitourinary Tract Including Gonorrhea
- Infections of the Respiratory Tract
- Infections of the Gastrointestinal Tract
- Meningitis
Categories
- Antibiotic
- Medication
- Pharmaceutical
Dosage
- Intra-articular
- Intraperitoneal
- Intrapleural
- Intravenous
- Oral
- Parenteral
- Septicaemia
RecommendedDosage
- Intra-articular:
- Adult: 500 mg daily
- Child: Half of adult routine dosage
- Intraperitoneal:
- Adult: 500 mg daily
- Child: Half of adult routine dosage
- Intrapleural:
- Adult: 500 mg daily
- Child: Half of adult routine dosage
- Intravenous:
- Meningitis:
- Adult: 2 gm 6 hrly
- Child: 150 mg/kg daily in divided doses
- Intrapartum prophylaxis against group B Streptoccocal infection in neonates: Initially, 2 gm via IV inj followed by 1 gm 4 hrly until delivery
- Meningitis:
- Oral:
- Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Otitis media, Perinatal streptococcal infections, Peritonitis:
- Adult: 0.25-1 gm 6 hrly
- Child: Half of adult routine dosage
- Typhoid and paratyphoid fever: 1-2 gm 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers
- Uncomplicated gonorrhoea: 2 gm with 1 gm of probenecid as single dose, recommended to be repeated in female patients
- Urinary tract infections: 500 mg 8 hrly
- Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Otitis media, Perinatal streptococcal infections, Peritonitis:
- Parenteral:
- Adult: 500 mg 6 hrly, via IM or slow IV inj over 3-5 min or by infusion
- Child: Half of adult routine dosage
- Septicaemia:
- Adult: 150-200 mg/kg daily. Initiate with IV admin for at least 3 days, then continue with IM inj 3-4 hrly
- Child: Same as adult dose
Administration
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals
Interaction
- May reduce the efficacy of oral contraceptives
- May alter INR while on warfarin and phenindione
- May reduce the efficacy of oral typhoid vaccines
- May reduce the excretion of methotrexate
- Reduced excretion with probenecid and sulfinpyrazone, resulting to increased risk of toxicity
- Allopurinol increases ampicillin-induced skin reactions
- Reduced absorption with chloroquine
- Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere with the bactericidal action of ampicillin
Contraindications
Hypersensitivity to ampicillin and other penicillins
SideEffects
- Nausea
- vomiting
- diarrhoea
- erythematous maculo-papular rashes
- sore mouth
- black/hairy tongue
- rash
- erythema multiforme
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- angioedema
- fever
- joint pains
- serum sickness-like symptoms
- haemolytic anaemia
- thrombocytopenia
- leucopenia
- neutropenia
- coagulation disorders
- prolonged bleeding time and prothrombin time
- CNS toxicity (e.g. convulsions)
- paraesthesia
- nephropathy
- interstitial nephritis
- hepatitis
- cholestatic jaundice
- moderate and transient increase in transaminases
- Anaphylaxis
- Clostridium difficile-associated diarrhoea (CDAD)
PregnancyAndLactation
Pregnancy Category B.
PrecautionsAndWarnings
- Patient with history of β-lactam allergy
- During renal impairment
- Pregnancy and lactation
UseInSpecialPopulations
- Renal Impairment: CrCl<10: Dose reduction or increase in dose interval
OverdoseEffects
- Symptoms: Nausea, vomiting and diarrhoea
- Management: Symptomatic and supportive treatment. May be removed from the circulation by haemodialysis
Reconstitution
- Intramuscular: Add 1.5 mL water for inj to 500 mg vial contents
- Intravenous: Dissolve 500 mg in 10 mL water for inj. May be added to infusion fluids or injected, suitably diluted into the drip tube
- Intra-articular: Dissolve 500 mg in up to 5 mL of water for inj or sterile procaine HCl 0.5% soln
- Intraperitoneal: Dissolve 500 mg in up to 10 mL water for inj
- Intrapleural: Dissolve 500 mg in 5-10 mL water for inj
StorageConditions
Store between 20-25° C. Reconstituted oral susp: Store between 2-8° C (discard after 14 days)
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