MFC 0.5% (Ophthalmic Solution)

Indications

• Treatment of bacterial conjunctivitis caused by susceptible strains of specific organisms
• Intraocular Antibiotic to prevent Postoperative Bacterial Endophthalmitis

Pharmacology

• Inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV
• Involvement in replication, transcription, and repair of bacterial DNA
• Key role in the partitioning of chromosomal DNA during bacterial cell division

Dosage & Administration

• One drop in the affected eye 3 times per day for 7 days (Eye Drops)
• Thin and even application to the affected eye 3 times a day for the first two days, and two times a day for the next five days (Eye Ointment)
• 0.2-0.4 ml dose prior to ocular surgery via intraocular route (Intraocular injection)

Interaction

• Inhibition of CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2 unlikely, indicating MFC is unlikely to alter the pharmacokinetics of drugs metabolized by these cytochrome P450 isozymes

Contraindications

• Hypersensitivity to Moxifloxacin, to other quinolones, or to any of the components in this medication

Side Effects

• Ocular adverse events: conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, subconjunctival hemorrhage, tearing
• Nonocular adverse events: fever, increased cough, infection, otitis media, pharyngitis, rash, rhinitis

Pregnancy & Lactation

• Use during pregnancy only if potential benefit justifies potential risk to the fetus
• Caution when administered to a nursing mother, as it can be presumed to be excreted in human milk

Precautions & Warnings

• Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi
• Examination with the aid of magnification if clinical judgment dictates
• Advice not to wear contact lenses if signs and symptoms of bacterial conjunctivitis present

Therapeutic Class

Ophthalmic antibacterial drugs

Storage Conditions

• Store below 25°C
• Do not freeze
• Store in cool and dry place, protected from light
• Keep out of the reach of children
• Do not touch dropper tip to any surface as this may contaminate MFC
• Do not use after one month of first opening

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