Aciflox 200 mg (Tablet)

Title

• Aciflox

Categories

• Antibacterial
• Medication
• Health

Description

• Aciflox is indicated for the treatment of adults with various infections caused by susceptible strains of microorganisms, including community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, chronic obstructive pulmonary disease (COPD), acute maxillary sinusitis, urinary tract infections, bacterial prostatitis, bacterial diarrhea, and osteomyelitis. It is also used for the treatment of tuberculosis in combination with rifampicin and isoniazid, and leprosy in combination with standard drugs.

Color Options

• N/A

Dimensions

• N/A

Functions

• Broad-spectrum antibacterial agent
• Inhibits DNA gyrase and topoisomerase IV
• Kills bacteria infecting the breathing airways and lungs

Materials

• Sparfloxacin

Technical Specifications

• Absolute oral bioavailability of 92%
• Oral absorption unaffected by administration with milk or food
• Distributes well into the body
• Low plasma protein binding at about 45%
• Metabolized by the liver primarily by phase II glucuronidation
• Excreted in both feces and urine

Design Elements

• N/A

Usability Features

• Loading dose on the first day followed by daily dose
• Recommended 10 days of therapy for patients with normal renal function
• Recommended 9 days of therapy for patients with renal impairment

Drug Interaction

• Forms chelation complexes with aluminium and magnesium cations in antacids and sucralfate
• May interact with medications known to produce an increase in the QTc interval and/or Torsade de pointes; does not interact with theophylline or caffeine, warfarin, cimetidine, or probenecid

Contraindications

• Hypersensitivity to any of its ingredients
• Pregnancy and lactation
• Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency
• History of Achilles tendinitis following the use of fluoroquinolones

Side Effects

• Mild to moderate in severity and transient in nature
• Most frequent side effects: Photosensitivity reaction, diarrhea, nausea, headache, dyspepsia, dizziness, insomnia, abdominal pain, pruritus, taste perversion, QTc interval prolongation, vomiting, flatulence, vasodilatation

Pregnancy and Lactation

• No adequate and well-controlled studies in pregnant women
• Use during pregnancy only if potential benefit justifies potential risk to the fetus

Precautions and Warnings

• Discontinue therapy at first signs or symptoms of phototoxicity reaction
• Safety and effectiveness not established in children, adolescents, pregnant women, and lactating women
• Adequate hydration to prevent highly concentrated urine
• Administer with caution in the presence of renal insufficiency
• Avoid concomitant prescription of medications known to prolong the QTc interval
• Avoid excessive sun exposure

Use in Special Populations

• Elderly: Pharmacokinetics not altered with normal renal function
• Paediatric: Pharmacokinetics not studied
• Gender: No gender differences in pharmacokinetics
• Renal insufficiency: Plasma concentrations typically twice those observed in subjects with normal renal function
• Hepatic impairment: Pharmacokinetics not altered in patients with mild or moderate hepatic impairment without cholestasis

Therapeutic Class

• 4-Quinolone preparations

Storage Conditions

• Keep out of the reach of children
• Store away from heat and direct light
• Store below 30°C

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