Sparlin 200 mg (Tablet)
Unit Price: ৳ 15.06 (1 x 10: ৳ 150.60)
Strip Price: ৳ 150.60
Medicine Details
| Category | Details |
|---|---|
| Generic | Sparfloxacin |
| Company | Beximco pharmaceuticals ltd |
Title and Categories
- Sparlin 200mg Tablet
- Antibacterial Agent
- Fluoroquinolone Antibiotic
- Prescription Medicine
Dimensions
- Each tablet: 200mg
- Packaging size: 10 tablets per pack
Color Options
- White
Functions
- Treats Community-acquired Pneumonia (CAP)
- Treats Acute Bacterial Exacerbations of Chronic Bronchitis (ABECB)
- Treats Urinary Tract Infections
- Treats Bacterial Diarrhoea
- Treats Osteomyelitis
- Treats Chronic Obstructive Pulmonary Disease (COPD)
- Treats Acute Maxillary Sinusitis (AMS)
- Treats Bacterial Prostatitis
- Treats Tuberculosis in combination with rifampicin and isoniazid
- Treats Leprosy in combination with standard drugs
Materials
- Active ingredient: Sparfloxacin
Technical Specifications
- Inhibits DNA gyrase and topoisomerase IV
- Broad-spectrum antibacterial agent
- Absorption: Oral bioavailability of 92%
- Distribution: Large mean steady-state volume of distribution
- Metabolism: Primarily by phase II glucuronidation
- Excretion: 50% in feces and 50% in urine
Design Elements
- Tablets
Usability Features
- Loading dose on the first day
- Different dosage for patients with renal impairment
Side Effects
- Photosensitivity reaction
- Diarrhea
- Nausea
- Headache
- Dyspepsia
- Dizziness
- Insomnia
- Abdominal pain
- Pruritus
- Taste perversion
- QTc interval prolongation
- Vomiting
- Flatulence
- Vasodilatation
Pregnancy & Lactation
- Use during pregnancy should be justified by benefit-risk analysis
Special Warnings
- Discontinue therapy at first signs of phototoxicity reaction
- Caution in children, adolescents, pregnant women, and lactating women
Precautions
- Maintain adequate hydration
- Administer with caution in renal insufficiency
- Avoid concomitant prescription of medications known to prolong the QTc interval
- Avoid excessive exposure to sunlight
Use in Special Populations
- No alteration in elderly with normal renal function
- No gender differences in pharmacokinetics
- Plasma concentrations in renal impairment patients are double
- No alteration in patients with mild or moderate hepatic impairment without cholestasis
Therapeutic Class
- 4-Quinolone preparations
Storage Conditions
- Keep out of reach of children
- Store away from heat and direct light
- Store below 30°C
Indications
- Indicated for the treatment of Community-acquired Pneumonia (CAP)
- Indicated for the treatment of Acute Bacterial Exacerbations of Chronic Bronchitis (ABECB)
- Also indicated for Chronic Obstructive Pulmonary Disease (COPD)
- Additional uses include treatment of tuberculosis in combination with rifampicin and isoniazid and treatment of leprosy in combination with standard drugs
Pharmacology
- Kills many types of bacteria infecting breathing airways and lungs
- More effective against some gram positive organisms, Mycobacteria, and Chlamydia spp.
- Well absorbed following oral administration
- Exhibits low plasma protein binding in serum
- Metabolized primarily by phase II glucuronidation
- Excreted in feces and urine
Dosage & Administration
- Recommended daily dose for patients with normal renal function: Two 200 mg tablets on the first day, then one 200 mg tablet every 24 hours for 10 days
Interaction
- Forms chelation complexes with aluminium and magnesium cations in antacids and sucralfate
- Does not interact with theophylline, caffeine, warfarin, cimetidine, and probenecid
Contraindications
- Hypersensitivity to any of its ingredients
- Pregnancy and lactation
- Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency
- History of Achilles tendinitis following the use of fluoroquinolones
Pediatric Uses
- Pharmacokinetics not studied in paediatric subjects
Storage and Usage
- Store below 30°C
- Keep away from heat and direct light
- Keep out of reach of children