Rimactane 450 mg (Tablet)
Unit Price: ৳ 10.86 (5 x 10: ৳ 542.75)
Strip Price: ৳ 108.55
Medicine Details
| Category | Details |
|---|---|
| Generic | Rifampicin |
| Company | Sandoz a novartis division |
Indications
- Treatment of tuberculosis
- Treatment of meningococcal carrier state
- Bacteriologic cultures confirmation
- Susceptibility monitoring
- Resistance tests
- Response to treatment monitoring
Pharmacology
- Suppression of chain formation for RNA synthesis
- Binding to β subunit of DNA-dependent RNA polymerase
- Blocking RNA transcription
Dosage
- Oral administration
- IV infusion
- Recommended oral administration once daily
- 10 mg/kg for adults
- 10-20 mg/kg for pediatric patients
- Three-drug regimen for initial phase of short-course therapy
- Continued treatment with rifampin and isoniazid for at least 4 months
Administration
- Take on an empty stomach
- Best taken 1 hour before or 2 hours after meals
Interaction
- May accelerate the metabolism of drugs metabolized by CYP450 enzymes
- Potential interactions with quinidine, phenytoin, theophylline, atovaquone, ketoconazole, enalaprilat, antacids, halothane, isoniazid
Contraindications
- Hypersensitivity to rifampin or any components
- Contraindicated with ritonavir-boosted saquinavir
- Contraindicated with atazanavir, darunavir, fosamprenavir, saquinavir, tipranavir
Side Effects
- Facial flushing and itching
- Flu-like syndrome
- GI adverse effects
- Pseudomembranous colitis
- Eosinophilia
- Leucopenia
- Hemolytic anemia
- Alterations in kidney function
- Menstrual disturbances
- Oedema
- Myopathy
- Orange-red discolouration of body fluids
- Thrombophlebitis
- Local irritation and inflammation after prolonged IV infusion
- Eye irritation
- Visual disturbances
- Anaphylaxis or shock
Pregnancy & Lactation
- Risk of postnatal hemorrhages when administered during the last few weeks of pregnancy
- Potential tumorigenicity shown in animal studies
- Decision making for nursing mothers
Precautions & Warnings
- Liver dysfunction
- Caution in patients with impaired liver function
- Hyperbilirubinemia and liver function monitoring
- Enzyme-inducing properties
- Association with porphyria exacerbation
- Caution in elderly patients
Use in Special Populations
- Caution in geriatric use
Overdose Effects
- Nausea
- Vomiting
- Abdominal pain
- Pruritus
- Headache
- Lethargy
- Unconsciousness in severe hepatic disease
- Transient increases in liver enzymes and/or bilirubin
- Brownish-red or orange discoloration of body fluids
- Liver enlargement
- Hypotension
- Cardiac arrhythmias
Therapeutic Class
- Anti-Tubercular Antibiotics
Reconstitution
- Preparation of solution for IV infusion
- Reconstitution of lyophilized powder
- Stability of reconstituted solution
- Preparation and infusion medium guidelines
Storage Conditions
- Store between 15-30° C
- Avoid excessive heat
- Protect from light