Rimstar 4-FDC 150 mg+75 mg+400 mg+275 mg (Tablet)
Unit Price: ৳ 17.00 (5 x 10: ৳ 850.00)
Strip Price: ৳ 170.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rifampicin isoniazid pyrazinamide ethambutol |
| Company | Sandoz a novartis division |
Indications
- treatment of pulmonary tuberculosis
- treatment of extrapulmonary tuberculosis
- intensive initial phase of treatment
Pharmacology
- bactericidal action
- sterilizing effect
- inhibition of RNA synthesis
- inhibition of cell wall biosynthesis
- slow diffusion into Mycobacteria cells
- impairment of cell metabolism
- arrest of cell multiplication
Dosage & Administration
- adult dosage
- dosage based on body weight
- daily dosage for 2 months
- dosing regimen for different body weights
Interaction
- induction of microsomal enzymes
- metabolism inhibition
- metabolism increase
- decreased efficacy of gout therapy agents
- neurotoxic interactions
Contraindications
- hypersensitivity to active ingredients
Side Effects
- reddish discolouration of body fluids
- liver enzyme elevation
- BUN & uric acid elevation
- hemolysis
- hematuria
- intestinal nephritis
- renal insufficiency
- GI discomfort
- CNS effects
- hematological changes
- skin rash
- endocrine effects
Pregnancy & Lactation
- crossing of placental barrier
- appearance in cord blood and maternal milk
- possible teratogenic potential
- observation for untoward effects on newborns
- potential teratogenicity
Precautions & Warnings
- impaired renal function
- impaired liver function
- diabetes mellitus
- chronic alcoholism
- undernourishment
- history of gout
- convulsive disorders
- acute porphyria
- elderly patients
- periodic blood counts
- liver function tests
- avoidance with soft contact lenses
- visual ability monitoring
- special precautions in children below 8 years
Use in Special Populations
- not recommended for use in children below 13 years
Therapeutic Class
- combined anti-tubercular preparations
Storage Conditions
- store at temperatures not exceeding 30°C