Xoviral 0.15% (Ophthalmic Gel)

Indications

• Topical eye antiviral
• Treatment of acute herpetic keratitis (dendritic ulcers)

Pharmacology

• Active ingredient: Ganciclovir
• Inhibits DNA replication by herpes simplex viruses (HSV)
• Transformed by viral and cellular thymidine kinases to ganciclovir triphosphate
• Competitive inhibition of viral DNA-polymerase
• Prevention of DNA replication

Dosage & Administration

• Recommended dosing regimen: 1 drop in the affected eye 5 times per day
• 1 drop 3 times per day for 7 days after corneal ulcer heals

Contraindications

• Known hypersensitivity to Ganciclovir

Side Effects

• Blurred vision (60%)
• Eye irritation (20%)
• Punctate keratitis (5%)
• Conjunctival hyperemia (5%)

Pregnancy & Lactation

• Pregnancy Category C
• Embryotoxic in rabbits and mice
• Caution in nursing mothers

Precautions & Warnings

• Topical eye use only
• Avoid wearing contact lenses during therapy

Use in Special Populations

• Pediatric Use: Safety and efficacy not established below the age of 2 years
• No observed overall differences in safety or effectiveness between elderly and younger patients

Overdose Effects

• Unlikely through local or accidental oral administration

Therapeutic Class

• Ophthalmic Anti-viral Products

Storage Conditions

• Store at 15°C to 30°C in a dry place protected from light
• Do not use more than one month after first opening of the tube

Related Brands

• Genclovir 0.15% (Ophthalmic Gel) - general-pharmaceuticals-ltd