Entavir 0.5 mg (Tablet)
Unit Price: ৳ 45.15 (1 x 14: ৳ 632.10)
Strip Price: ৳ 632.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Entecavir |
| Company | Drug international ltd |
| Also available as |
Indications
- Treatment of chronic hepatitis B virus infection in adults and pediatric patients
- Evidence of active viral replication
- Elevation in serum aminotransferases
- Histologically active disease
Pharmacology
- Competes with natural substrate deoxyguanosine triphosphate
- Inhibits all three activities of the HBV polymerase
- Activation by kinases
- Incorporation into DNA
- Inhibits HBV polymerase activity
Dosage & Administration
- Recommended dose for nucleoside-treatment-naive adults and adolescents
- Recommended dose for Lamivudine-refractory or known Lamivudine or Telbivudine resistance mutations
- Recommended dose for patients with decompensated liver disease
- Should be administered on an empty stomach
- Instructions for missed dose
Interaction
- Co-administration with Lamivudine or Adefovir dipivoxil
- Effects on drugs eliminated through renal function
- Monitoring for adverse events
Contraindications
- Hypersensitivity to Entecavir or any component of the product
Side Effects
- Most common adverse events: headache, fatigue, dizziness, nausea
Pregnancy & Lactation
- Effect on transmission of HBV from mother to infant
- Excretion in human milk
- Instruction not to breastfeed
Precautions & Warnings
- Lactic acidosis and severe hepatomegaly with steatosis
- Exacerbations of hepatitis after discontinuation of treatment
Use in Special Populations
- Safety and effectiveness in pediatric patients below the age of 2 years
- Safety in geriatric patients
- Dose adjustment in renal impairment
Overdose Effects
- No reported experience of Entavir overdosage in patients
- Healthy subject test results
- Monitoring for evidence of toxicity
- Standard supportive treatment
Therapeutic Class
- Hepatic viral infections (Hepatitis B)
Storage Conditions
- Storage temperature below 30°C
- Protection from light
- Keep out of reach of children