Genevir 1 mg (Tablet)
Unit Price: ৳ 90.27 (1 x 10: ৳ 902.70)
Strip Price: ৳ 902.70
Medicine Details
| Category | Details |
|---|---|
| Generic | Entecavir |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- For the treatment of chronic hepatitis B virus infection in adults and pediatric patients 2 years of age and older with evidence of active viral replication and either evidence of persistent elevation in serum aminotransferases (ALT or AST) or histologically active disease
Pharmacology
- Inhibits all three activities of the HBV polymerase, including base priming, reverse transcription of the negative strand from the pregenomic messenger RNA, and synthesis of the positive strand of HBV DNA
Dosage & Administration
- Recommended dose for chronic hepatitis B virus infection in nucleoside-treatment-naive adults and adolescents 16 years of age is 0.5 mg once daily
- Recommended dose for Lamivudine-refractory or known Lamivudine or Telbivudine resistance mutations is 1 mg once daily
- Recommended dose for patients with decompensated liver disease (adult) is 1 mg once daily
- Administered on an empty stomach
- Instructions for missed dose
Interaction
- Information about co-administration with Lamivudine or Adefovir dipivoxil
- Adverse event monitoring for co-administration with drugs eliminated through renal or affecting renal function
Contraindications
- Entecavir is contraindicated in patients with previously demonstrated hypersensitivity to Entecavir or any component of the product
Side Effects
- The most common adverse events are headache, fatigue, dizziness, and nausea
Pregnancy & Lactation
- No data on the effect of Entecavir on the transmission of HBV from mother to infant
- Advice on breastfeeding while taking Entecavir
Precautions & Warnings
- Lactic acidosis
- Exacerbations of hepatitis after discontinuation of treatment
Use in Special Populations
- Safety and effectiveness in pediatric patients below the age of 2 years not established
- Caution in dose selection for geriatric patients
- Dose adjustment in renal impairment based on creatinine clearance
Overdose Effects
- No experience of Genevir overdosage reported in patients
- General guidance for monitoring and supportive treatment in case of overdosage
Therapeutic Class
- Hepatic viral infections (Hepatitis B)
Storage Conditions
- Instructions for storage below 30°C, protection from light, and keeping out of the reach of children