Tenvira 300 mg (Tablet)

Unit Price: ৳ 80.00 (1 x 10: ৳ 800.00)
Strip Price: ৳ 800.00

Medicine Details

Category Details
Generic Tenofovir disoproxil
Company Aristopharma ltd

Indications

  • Treatment of HIV-1 infection
  • Treatment of chronic hepatitis B in adults

Pharmacology

  • Mechanism of action: Inhibition of HIV reverse transcriptase
  • Pharmacokinetics: Water-soluble diester prodrug of Tenofovir
  • Oral bioavailability of approximately 25%
  • Maximum serum concentrations achieved in 1.0-10.4 hrs
  • Low protein binding to plasma and serum proteins
  • Half-life of approximately 17 hours
  • Elimination by glomerular filtration and active tubular secretion

Dosage & Administration

  • Size and frequency of dosage must be adjusted to individual patient
  • Adult dose: 245 mg Tenofovir tablet once daily, orally, regardless of food
  • Pediatric dose (12 years and older, ≥35 kg): 245 mg Tenofovir tablet once daily, orally, regardless of food

Interaction

  • Coadministration caution with didanosine and close monitoring for adverse reactions
  • Monitoring for adverse reactions when used with atazanavir, lopinavir, ritonavir

Contraindications

  • Broken bone due to disease or illness
  • Enlarged fatty liver
  • Severe liver disease
  • Acute kidney disease
  • Decreased bone calcification or density
  • Breastfeeding mother
  • Low phosphate levels in blood
  • Increased blood acidity due to high lactic acid levels
  • Overweight

Side Effects

  • Common: Headache, diarrhea, nausea, weakness
  • Other possible: Indigestion, heartburn, chest pain, drowsiness
  • Report immediately: High cholesterol, kidney problems, depression, anxiety

Pregnancy & Lactation

  • Pregnancy category B
  • Use during pregnancy only if clearly needed
  • CDC recommendation against breastfeeding by HIV-1-infected mothers

Precautions & Warnings

  • Lactic acidosis and severe hepatomegaly with steatosis reported
  • Exacerbation of hepatitis after treatment discontinuation
  • New onset or worsening renal impairment possible
  • Avoid use with certain combination products and adefovir disoproxil
  • Use caution in HIV-1 and HBV coinfected patients
  • Potential for fat redistribution, immune reconstitution syndrome
  • Dose adjustment for renal impairment

Use in Special Populations

  • Dose adjustment for renal impairment in adults
  • Increased drug exposures in moderate to severe renal impairment
  • No adjustment necessary for mild renal impairment

Therapeutic Class

  • Drugs for HIV / Anti-retroviral drugs
  • Hepatic viral infections (Hepatitis B)

Storage Conditions

  • Do not store above 25°C
  • Store in cool, dry place protected from light
  • Keep out of children's reach

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