Optipeg-A 180 mcg/0.5 ml (SC Injection)

0.5 ml pre-filled syringe: ৳ 9,800.00

Medicine Details

Indications

  • Treatment of chronic hepatitis C in adults
  • Treatment of chronic hepatitis B in adults

Pharmacology

  • Higher and more prolonged serum interferon concentrations
  • Antiviral, antiproliferative, and immune-regulating activity

Dosage & Administration

  • Recommended dose of Peg interferon is 180 mcg once weekly for 48 weeks
  • Subcutaneous administration on abdomen or thigh
  • Different dosages for Hepatitis C Genotype 1 & 4 and Genotype 2 & 3

Interaction

  • Drugs metabolized by CYP1A2
  • Methadone monitoring
  • Nucleoside analogues monitoring
  • Zidovudine monitoring
  • Azathioprine interaction

Contraindications

  • Hypersensitivity to any component
  • Autoimmune hepatitis
  • Hepatic decompensation in cirrhotic patients
  • Neonate or infants

Side Effects

  • Depression and suicide risk
  • Flu-like symptoms
  • Gastrointestinal issues
  • Metabolic and Nutritional effects
  • Musculoskeletal effects
  • Neurological effects
  • Psychiatric reactions
  • Injection site reaction and skin problems
  • Endocrine effects

Pregnancy & Lactation

  • Pregnancy Category C
  • Recommended for use with effective contraception during therapy
  • Potential adverse reactions in nursing infants

Precautions & Warnings

  • Patients who have failed alpha interferon treatment
  • Transplant recipients
  • Coinfected patients with HCV or HIV
  • Caution for patients with baseline risk of severe anemia

Use in Special Populations

  • Dose modification for hepatic impairment
  • Dose modification for adverse reactions
  • Dose modification for depression
  • Use caution in renal impairment

Overdose Effects

  • Limited experiences of overdose
  • No serious reactions attributed to overdose
  • No specific antidote
  • Dialysis not effective

Therapeutic Class

  • Hepatic viral infections (Hepatitis B)
  • Hepatic viral infections (Hepatitis C)

Storage Conditions

  • Store in refrigerator at 2-8°C
  • Do not freeze or shake
  • Protect from light

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