Optipeg-A 180 mcg/0.5 ml (SC Injection)
0.5 ml pre-filled syringe: ৳ 9,800.00
Medicine Details
Category | Details |
---|---|
Generic | Peginterferon alfa 2a pegylated interferon alfa 2a |
Company | Incepta pharmaceuticals ltd |
Also available as |
Indications
- Treatment of chronic hepatitis C in adults
- Treatment of chronic hepatitis B in adults
Pharmacology
- Higher and more prolonged serum interferon concentrations
- Antiviral, antiproliferative, and immune-regulating activity
Dosage & Administration
- Recommended dose of Peg interferon is 180 mcg once weekly for 48 weeks
- Subcutaneous administration on abdomen or thigh
- Different dosages for Hepatitis C Genotype 1 & 4 and Genotype 2 & 3
Interaction
- Drugs metabolized by CYP1A2
- Methadone monitoring
- Nucleoside analogues monitoring
- Zidovudine monitoring
- Azathioprine interaction
Contraindications
- Hypersensitivity to any component
- Autoimmune hepatitis
- Hepatic decompensation in cirrhotic patients
- Neonate or infants
Side Effects
- Depression and suicide risk
- Flu-like symptoms
- Gastrointestinal issues
- Metabolic and Nutritional effects
- Musculoskeletal effects
- Neurological effects
- Psychiatric reactions
- Injection site reaction and skin problems
- Endocrine effects
Pregnancy & Lactation
- Pregnancy Category C
- Recommended for use with effective contraception during therapy
- Potential adverse reactions in nursing infants
Precautions & Warnings
- Patients who have failed alpha interferon treatment
- Transplant recipients
- Coinfected patients with HCV or HIV
- Caution for patients with baseline risk of severe anemia
Use in Special Populations
- Dose modification for hepatic impairment
- Dose modification for adverse reactions
- Dose modification for depression
- Use caution in renal impairment
Overdose Effects
- Limited experiences of overdose
- No serious reactions attributed to overdose
- No specific antidote
- Dialysis not effective
Therapeutic Class
- Hepatic viral infections (Hepatitis B)
- Hepatic viral infections (Hepatitis C)
Storage Conditions
- Store in refrigerator at 2-8°C
- Do not freeze or shake
- Protect from light