G-G Vin 500 mg (Tablet)

Unit Price: ৳ 4.00 (50's pack: ৳ 200.00)

Medicine Details

Category	Details
Generic	Griseofulvin microsize
Company	Gonoshasthaya pharma ltd

Indications

Tinea capitis (ringworm of the scalp)
Tinea corporis (ringworm of the body)
Tinea pedis (athlete's foot)
Tinea unguium (onychomycosis; ringworm of the nails)
Tinea cruris (ringworm of the thigh)
Tinea barbae (barber's itch)

Major fungi inhibits

Trichophyton rubrum
Trichophyton tonsurans
Trichophyton mentagrophytes
Trichophyton interdigitalis
Trichophyton verrucosum
Trichophyton sulphureum
Trichophyton schoenleini
Microsporum audouini
Microsporum canis
Microsporum gypseum
Epidermophyton floccosum
Trichophyton megnini
Trichophyton gallinae
Trichophyton crateriform

Pharmacology

Fungistatic, inhibits fungal cell mitosis and nuclear acid synthesis, interferes with spindle and cytoplasmic microtubules by binding to alpha and beta tubulin, binds to keratin in human cells and fungal microtubes altering the mitosis

Dosage

Accurate diagnosis: Essential, by direct microscopic examination or culture on appropriate medium
Medication duration:
- Tinea capitis: 4 to 6 weeks
- Tinea corporis: 2 to 4 weeks
- Tinea pedis: 4 to 8 weeks
- Tinea unguium fingernails: at least 4 months
- Tinea unguium toenails: at least 6 months
General measures: Hygiene control, concomitant use of topical agents may be required

Administration

Should be taken with food, immediately after meals

Interaction

Warfarin interaction: May require dosage adjustment
Barbiturates interaction: May depress the activity of G-G Vin
Oral contraceptives interaction: May reduce efficacy and increase the incidence of breakthrough bleeding

Contraindications

Contraindicated in:
- patients with porphyria
- hepatocellular failure
- individuals with a history of hypersensitivity to griseofulvin
Pregnancy contraindication: Two cases of conjoined twins reported, should not be prescribed to pregnant patients

Side Effects

Hypersensitivity reactions:
- skin rashes
- urticaria
- angioneurotic edema
- erythema multiforme-like drug reaction
Other side effects:
- Paresthesias of the hands and feet
- oral thrush
- nausea
- vomiting
- epigastric distress
- diarrhea
- headache
- fatigue
- dizziness
- insomnia
- mental confusion
- impairment of routine activities
- Proteinuria
- Leukopenia

Pregnancy and Lactation

Pregnancy Category C, potential benefit justifying the potential risk to the fetus

Precautions and Warnings

Close observation: Patients on prolonged therapy with any potent medication should be under close observation, periodic monitoring of organ system function should be done
Cross sensitivity: Cross sensitivity with penicillin exists
Photosensitivity reaction: Patients should be warned to avoid exposure to intense natural or artificial sunlight