Anfasil 50 mg (Tablet)
Unit Price: ৳ 7.00 (5 x 6: ৳ 210.00)
Strip Price: ৳ 42.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Silva pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea infections
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections
- Cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infections in neutropenic cancer patients
- Acute treatment of systemic fungal infections like coccidioidomycosis and histoplasmosis
Pharmacology
- Triazole antifungal agent
- Inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for synthesis of ergosterol in fungal cell membrane
Dosage & Administration
- Different dosages for various infections
- Single doses and multiple dose regimens
- Dosage adjustments for children and patients with renal impairment
- Specific dosing instructions for elderly patients
Interactions
- Interaction with warfarin
- Interaction with sulphonylureas
- Interaction with hydrochlorothiazide
- Interaction with phenytoin
- Interaction with rifampicin
- Interaction with oral contraceptives
- Interaction with cyclosporin
- Effect of food on absorption
- Interaction with theophylline
Contraindications
- Known hypersensitivity to fluconazole or related triazole compounds
Side Effects
- Gastrointestinal symptoms
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rare cases of allergic reactions like rash
- Rare cases of anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects in animal studies
- Not recommended during pregnancy or lactation without adequate contraception
Precautions & Warnings
- Monitoring required for hepatic, renal, haematological function
- Rare cases of hepatic necrosis
- Exfoliative cutaneous reactions
- Stevens Johnson Syndrome and toxic epidermal necrolysis
- Use in lactation
- No impairment of driving or machinery use expected
Use in Special Populations
- Elderly patients dosage adjustment
- Renal impairment dosage modification
- Excretion in urine
- Adjustments based on creatinine clearance
- Specific instructions for haemodialysis patients
Overdose Effects
- Supportive measures
- Symptomatic treatment
- Gastric lavage if required
- Forced diuresis for elimination enhancement
- Haemodialysis efficacy
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Dry place
- Away from light and heat
- Keep out of reach of children