Alphanate 250 IU/vial (Injection)
250 IU vial: ৳ 9,900.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Antihemophilic factor factor viii |
| Company | Grifols biologicals llc |
Indications
- Treatment of haemorrhagic episodes in patients with haemophilia A
- Prophylaxis in severe haemophilia A
Pharmacology
- Factor VIII required for clot formation
- Activation of factor X and IX
- Conversion of prothrombin to thrombin
- Formation of fibrin and stable clot with factor XIII
- Replacement therapy in patients with haemophilia A
Dosage & Administration
- Individualized dosage based on coagulation tests
- Approximate increase of 2 IU/dL with 1 IU/kg
- Recommended doses for different severity levels of haemorrhage
- Prophylaxis dosage for severe haemophilia A
Interaction
- Allergic reactions
- Chills
- Chest tightness
- Fever
- Headache
- Nausea
- Vomiting
- Stomach discomfort
- Urticaria
- Vasomotor reactions with rapid infusion
Contraindications
- Anaphylactic or severe systemic reaction to antihemophilic factor preparations
Side Effects
- Allergic reactions
- Chills
- Chest tightness
- Fever
- Headache
- Nausea
- Vomiting
- Stomach discomfort
- Urticaria
- Vasomotor reactions with rapid infusion
Pregnancy & Lactation
- Pregnancy Category C
- Potential risk to the fetus
Precautions & Warnings
- Risk of intravascular haemolysis in patients with specific blood groups
- Risk of viral infections transmission
- Optimal treatment based on clinical response
- Regular monitoring of platelet counts
Therapeutic Class
- Antihaemophilic factor
Reconstitution
- Intravenous reconstitution process
- Warm-up requirement for refrigerated concentrate and diluent
Storage Conditions
- Store between 2-8°C
- Use within 3 hr of reconstitution
- Avoid refrigeration after reconstitution