Canazole 50 mg (Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Fluconazole
Company Aci limited
Also available as
Canazole 150 mg tablet Canazole 200 mg tablet Canazole 50 mg suspension

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Superficial Candidiasis
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Fluconazole is a triazole antifungal agent and a potent inhibitor of fungal cytochrome P-450 dependent enzymes.

Dosage & Administration

  • Adults:
    • Vaginal Candidiasis: 150 mg as a single dose
    • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
    • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
    • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
    • Kerion: 50 mg daily for 20 days
    • Pityriasis versicolor: 400 mg as a single dose
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
    • Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
    • Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
  • Child Over 1 Year:
    • In Superficial Candidiasis: 1-2 mg/kg daily
    • In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily

Interaction

  • Potential interaction with warfarin, sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, and combined oral contraceptives
  • May prolong the serum half-life of concomitantly administered drugs

Contraindications

Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds.

Side Effects

  • Nausea
  • Abdominal discomfort
  • Diarrhea
  • Flatulence
  • Rarely encountered adverse events like rash (Incidence less than 1%)
  • Rare cases of anaphylaxis

Pregnancy & Lactation

Fluconazole should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed.

Precautions & Warnings

  • Abnormalities of hepatic, renal, hematological, and other biochemical function tests observed in some patients
  • Rare cases of hepatic necrosis reported
  • Patients may develop severe cutaneous reactions
  • Use during lactation not recommended

Use in Special Populations

  • Elderly: Normal dose should be used if there is no evidence of renal impairment
  • Renal Impairment: Dosage intervals or daily dosage should be modified based on creatinine clearance

Overdose Effects

Supportive measures and symptomatic treatment may be adequate; forced volume diuresis may increase the elimination rate; haemodialysis decreases plasma levels by approximately 50%

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Keep in a dry place away from light and heat, out of the reach of children

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