Canazole 200 mg (Tablet)
Unit Price: ৳ 25.08 (1 x 10: ৳ 250.80)
Strip Price: ৳ 250.80
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Aci limited |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis
- Tinea cruris
- Tinea pedis
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections
- Cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections
Pharmacology
- Triazole antifungal agent
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol
Dosage & Administration
- Various dosage for different indications
- Dosage adjustments for children, elderly, and patients with renal impairment
- Use in specific population
Interaction
- Increased prothrombin time with warfarin
- Prolonged serum half-life of oral sulphonylureas
- Increased plasma concentrations of hydrochlorothiazide
- Increased level of phenytoin
- Decreased AUC and shorter half-life with rifampicin
- No relevant effects on combined oral contraceptives
- Slowly increased cyclosporin concentrations
- No impairment of absorption with food, cimetidine, or antacids
- Decrease in plasma clearance of theophylline
Contraindications
- Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Gastrointestinal symptoms
- Rarely encountered rash
- Rare cases of anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects seen in animals at high dose levels
- Not recommended in pregnancy or women of childbearing potential
Precautions & Warnings
- Observation of hepatic, renal, and hematological function tests
- Assessment of risk-benefit ratio in patients with significant rise of liver enzymes
- Rarely developed exfoliative cutaneous reactions
- Use in lactating mothers not recommended
- Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Normal dose in the elderly if no evidence of renal impairment
- Dosage adjustments in renal impairment based on creatinine clearance
Overdose Effects
- Supportive measures and symptomatic treatment
- Forced volume diuresis may increase elimination rate
- Haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children