Canazole 50 mg/5 ml (Powder for Suspension)

35 ml bottle: ৳ 78.53

Medicine Details

Category Details
Generic Fluconazole
Company Aci limited
Also available as
Canazole 50 mg tablet Canazole 150 mg tablet Canazole 200 mg tablet

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients.
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis.

Pharmacology

Potent inhibitor of fungal cytochrome P-450 dependent enzymes

Dosage & Administration

  • Adults:
    • Vaginal Candidiasis: 150 mg as a single dose
    • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
    • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
    • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
    • Kerion: 50 mg daily for 20 days
    • Pityriasis versicolor: 400 mg as a single dose
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
    • Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
    • Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
  • Use in Specific Population:
    • Elderly patient: The normal dose should be used if there is no evidence of renal impairment
    • Renal Impairment: Dosage intervals should be modified as per creatinine clearance

Interaction

  • Interacts with warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, oral contraceptives, cyclosporin, food, cimetidine, antacids, theophylline

Contraindications

Should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

  • Common: Nausea, abdominal discomfort, diarrhea, flatulence
  • Rare: Rash, anaphylaxis

Pregnancy & Lactation

Should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed

Precautions & Warnings

  • Abnormalities: Observation of hepatic, renal, hematological and other biochemical function tests
  • Hepatic Necrosis: Assess risk-benefit ratio in patients with significant rise of liver enzymes
  • Cutaneous Reactions: Rarely patients have developed exfoliative cutaneous reactions, Stevens Johnson Syndrome, and toxic epidermal necrolysis
  • Lactation: Found in human breast milk at concentrations similar to plasma, not recommended for use in nursing mothers
  • Driving/Use of machinery: Unlikely to impair a patient's ability to drive or use machinery

Use in Special Populations

  • Elderly: Normal dose should be used if there is no evidence of renal impairment
  • Renal Impairment: Dosage intervals or daily dosage should be modified in accordance with creatinine clearance

Overdose Effects

Supportive measures, symptomatic treatment, gastric lavage, and forced volume diuresis may be adequate

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Keep in a dry place away from light and heat, keep out of the reach of children

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