Candid 150 mg (Tablet)
Unit Price: ৳ 22.00 (20's pack: ৳ 440.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Amico laboratories ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Potent inhibitor of fungal cytochrome P-450 dependent enzymes
Dosage & Administration
- Adults:
- 150 mg as a single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
- 150 mg weekly for 4-6 weeks for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis versicolor
- 150 mg weekly for 12 months for Onychomycosis
- 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections
- 200 mg daily for Prevention of cryptococcal meningitis
- 50-400 mg daily for Prevention of fungal infections in immunocompromised patients
- Child over 1 year:
- 1-2 mg/kg daily for Superficial Candidiasis
- 3-6 mg/kg daily for Systemic Candidiasis & Cryptococcal infection
- Use in Specific Population:
- Elderly patient: Normal dose if no evidence of renal impairment
- Renal Impairment: Dosage interval modification based on creatinine clearance
Interaction
- Increased prothombin time after warfarin administration
- Prolonged serum half-life of oral sulphonyl ureas
- Increased plasma concentrations of fuconazole by 40% when co-administered with hydrochlorothiazide
- Increased the level of phenytoin
- Decrease in the AUC and shorter half-life of fuconazole when co-administered with rifampicin
- Increased AUCs of ethinyl estradiol and levonorgestrel when co-administered with oral contraceptive
- Slow increase of cyclosporin concentrations
Contraindications
Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rash
- Anaphylaxis
Pregnancy & Lactation
Not recommended for use in pregnancy or in women of child bearing potential unless adequate contraception is employed
Precautions & Warnings
- Hepatic, renal, haematological and other biochemical function tests abnormalities: Observed in some patients
- Hepatic necrosis: Very rarely observed, risk-beneft ratio assessment required
- Exfoliative cutaneous reactions: Rarely observed, especially in AIDS patients
- Use during lactation: Not recommended
- Driving/Use of machinery: Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Elderly: Normal dose if no evidence of renal impairment
- Renal Impairment: Dosage interval modification based on creatinine clearance
Overdose Effects
Supportive measures, symptomatic treatment, forced volume diuresis, haemodialysis
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Dry place, away from light and heat, keep out of the reach of children