Conazole 50 mg (Capsule)

Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)

Medicine Details

Category	Details
Generic	Fluconazole
Company	Apollo pharmaceutical ltd

Indications

Vaginal Candidiasis
Oropharyngeal Candidiasis
Oesophageal Candidiasis
Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
Kerion
Pityriasis versicolor
Onychomycosis
Invasive candidal infections and cryptococcal infections (including meningitis)
Prevention of cryptococcal meningitis
Prevention of fungal infections in immunocompromised patients
Systemic Candidiasis and Cryptococcal infection
Superficial Candidiasis
Fungal urinary tract infections
Disseminated candidiasis
Prophylaxis for fungal infection in neutropenic cancer patients
Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Triazole antifungal agent, potent inhibitor of fungal cytochrome P-450 dependent enzymes, responsible for the synthesis of ergosterol

Dosage & Administration

Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
Child over 1 year:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
- Serious life threatening infections upto 12 mg/kg daily has been given to children aged 5-13 years (Maximum 400 mg daily)
Specific Population:
- Elderly patient: Use normal dose if no evidence of renal impairment
- Renal Impairment:
  - Creatinine clearance (>41 ml/min): Dosage interval (hours) 24
  - Creatinine clearance (21-40 ml/min): Dosage interval (hours) 48
  - Creatinine clearance (10-20 ml/min): Dosage interval (hours) 72
  - Patients receiving regular dialysis: One dose after every dialysis session
- Children: Renal clearance may be proportionately more rapid than in adults, doses up to 12 mg/kg is recommended

Interaction

Increased prothrombin time after warfarin administration
Prolonged serum half-life of concomitantly administed oral sulphonyl ureas
Co-administration of multiple-dose hydrochlorothiazide to healthy volunteers increased plasma concentrations of fuconazole by 40%
Increase in the level of phenytoin
Co-administration with rifampicin resulted in a 25% decrease in the AUC and 20% shorter half-life of fuconazole
No relevant effects on hormone levels in the 50 mg fuconazole study
Potential increase of cyclosporin concentrations

Contraindications

Not to be used in patients with known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

Nausea
Abdominal discomfort
Diarrhoea
Fatulence
Rare adverse events such as rash (Incidence less than 1%)
Rarely reported anaphylaxis

Pregnancy & Lactation

Not recommended for use in pregnancy or in women of child bearing potential unless adequate contraception is employed

Precautions & Warnings

Abnormalities of hepatic, renal, haematological and other biochemical function tests observed in some patients
Rare cases of hepatic necrosis observed
Rare development of exfoliative cutaneous reactions
Not recommended for use during lactation
Unlikely to impair a patient's ability to drive or use machinery

Use in Special Populations

Elderly: Use normal dose if no evidence of renal impairment
Renal Impairment:
- CrCl >40: Dosage interval 24 hours (normal dosage regimen)
- CrCl 21-40: Dosage interval 48 hours or half normal daily dose
- CrCl 10-20: Dosage interval 72 hours or one-third normal daily dose
- Patients receiving regular haemodialysis: One dose after every dialysis session

Overdose Effects

Supportive measures and symptomatic treatment recommended, forced volume diuresis may increase the elimination rate