Flucanex 50 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Jenphar bangladesh ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes.
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
- Child over 1 year:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection:3-6 mg/kg daily
- Use in Specific Population:
- Elderly patient: The normal dose should be used if there is no evidence of renal impairment
- Renal Impairment: Adjust dosage intervals based on creatinine clearance
Interaction
- Increased prothrombin time after warfarin administration
- Prolonged serum half-life of concomitantly administed oral sulphonyl ureas
- Increased plasma concentrations of fuconazole by 40% when co-administered with hydrochlorothiazide
- Increased level of phenytoin
- Decrease in the AUC and shorter half-life of fuconazole when co-administered with rifampicin
- Potential effects on oral contraceptives and cyclosporin concentrations
- No clinically significant impairment of fuconazole absorption when co-administered with food, cemetidine, antacids, or following total body irradiation
- 18% decrease in the mean plasma clearance of theophyline when co-administered with fuconazole
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds
Side Effects
Nausea, abdominal discomfort, diarrhoea, flatulence, rash, and rare cases of anaphylaxis
Pregnancy & Lactation
Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity
Precautions & Warnings
Abnormalities of hepatic, renal, haematological and other biochemical function tests observed in some patients, rare cases of hepatic necrosis, exfoliative cutaneous reactions, caution in lactation, and unlikely impairment of a patient's ability to drive or use machinery
Use in Special Populations
- Use in the elderly: The normal dose should be used if there is no evidence of renal impairment
- Use in renal impairment: Adjust dosage intervals or daily dosage based on creatinine clearance
Overdose Effects
Supportive measures and symptomatic treatment with gastric lavage if necessary, forced volume diuresis may increase the elimination rate, and haemodialysis can decrease plasma levels by approximately 50%
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children