Flucoder 50 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Potent inhibitor of fungal cytochrome P-450 dependent enzymes responsible for the synthesis of ergosterol
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
Interaction
Fluconazole interacts with various drugs such as warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, theophyline, and food, cemetidine, antacids
Contraindications
Should not be used in patients with known hypersensitivity to fluconazole or related triazole compounds
Side Effects
Common side effects associated with gastrointestinal tract, nausea, abdominal discomfort, diarrhea, flatulence. Rare adverse events include rash and anaphylaxis
Pregnancy & Lactation
Adverse fetal effects seen in animals at dose levels associated with maternal toxicity, hence not recommended in pregnancy or in women of childbearing potential unless adequate contraception is employed
Precautions & Warnings
Abnormalities of hepatic, renal, and biochemical function tests observed in some patients. Rare cases of hepatic necrosis, exfoliative cutaneous reactions, and anaphylaxis reported. Not recommended during lactation. Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Elderly: Use normal dose if no evidence of renal impairment
- Renal Impairment: No adjustments in single dose therapy required. Multiple dose therapy should be adjusted based on creatinine clearance
Overdose Effects
Supportive measures and symptomatic treatment recommended. Forced volume diuresis may increase elimination rate. Haemodialysis decreases plasma levels by approximately 50%