Flucoder 150 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis
- Tinea cruris
- Tinea pedis
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections
- Cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections
Pharmacology
Fluconazole is a triazole antifungal agent and a potent inhibitor of fungal cytochrome P-450 dependent enzymes, essential for the synthesis of ergosterol in fungal cell membranes.
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
- Children:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
- Use in Specific Population:
- Elderly patient: Normal dose if no evidence of renal impairment
- Renal Impairment: Dosage intervals or daily dosage should be modified based on creatinine clearance
Interaction
- Warfarin
- Sulphonyl ureas
- Hydrochlorothiazide
- Phenytoin
- Rifampicin
- Oral contraceptives
- Cyclosporin
- Cimetidine
- Theophylline
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds.
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rash
- Anaphylaxis
Pregnancy & Lactation
Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity. Its use in pregnancy or in women of childbearing potential is not recommended unless adequate contraception is employed.
Precautions & Warnings
- Abnormalities of hepatic, renal, haematological and other biochemical function tests
- Potential hepatic necrosis
- Exfoliative cutaneous reactions
- Use during lactation not recommended
- Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Use in the elderly: Normal dose if no evidence of renal impairment
- Use in renal impairment: Dosage intervals or daily dosage should be adjusted based on creatinine clearance
Overdose Effects
In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage may be adequate. Haemodialysis decreases plasma levels by approximately 50%.
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.