Flucolet 50 mg (Capsule)
Unit Price: ৳ 8.03 (30's pack: ৳ 240.90)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Amulet pharmaceuticals ltd |
| Also available as |
Title
- Flucolet
Categories
- Antifungal Medicine
- Pharmaceuticals
- Medication
- Healthcare
Description
- Fluconazole is a triazole antifungal agent
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Indicated for various fungal infections including Candidiasis, Tinea, and Onychomycosis
- Dosage and Administration instructions for different indications and age groups
- Interactions with other medications such as warfarin, hydrochlorothiazide, phenytoin, and oral contraceptives
- Contraindications, Side Effects, Pregnancy & Lactation precautions, and Overdose Effects
Color Options
- N/A
Dimensions
- N/A
Functions
- Antifungal treatment
- Inhibitor of fungal cell membrane synthesis of ergosterol
- Prevention of fungal infections in immunocompromised patients
Materials
- Active ingredient: Fluconazole
Technical Specifications
- Dosage: 150-400 mg for adults based on indication
- Dosage for children based on indication and age/weight
- Renal Impairment dosage adjustments based on creatinine clearance
- Cautions for elderly patients
Design Elements
- Triazole antifungal class
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Oral and IV administration
Usability Features
- Single-dose treatment for some indications
- Dosage adjustments for renal impairment
- Contraindicated for patients with known hypersensitivity to Fluconazole
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis
- Tinea cruris
- Tinea pedis
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections
- Cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of systemic fungal infections
Pharmacology
- Triazole antifungal agent
- Inhibition of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol in fungal cell membrane
Dosage & Administration Instructions
- Specific dosages for different types of Candidiasis
- Dosage for Tinea infections
- Dosage for Onychomycosis
- Dosage for invasive candidal infections and cryptococcal infections
- Dosage adjustments for children based on weight/age
- Dosage adjustments for renal impairment based on creatinine clearance
- Cautions for elderly patients
Interaction
- Effect on prothrombin time when used with warfarin
- Prolonged serum half-life of oral sulphonyl ureas when co-administered with Flucolet
- Effect on plasma concentrations when co-administered with hydrochlorothiazide
- Increased levels of phenytoin when co-administered
- Affect on hormonal levels when co-administered with combined oral contraceptives
- Effect on cyclosporin concentrations
- Absorption with co-administration of food, cimetidine, antacids, or total body irradiation
- Effect on theophylline clearance
Contraindications
- Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Gastrointestinal symptoms
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rarely encountered rash
- Rare cases of anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects in animals at high dose levels
- Use not recommended in pregnancy or nursing mothers unless adequate contraception is employed
- Flucolet found in human breast milk at concentrations similar to plasma
Precautions & Warnings
- Abnormalities of hepatic, renal, haematological, and biochemical function tests in some patients
- Rare occurrences of hepatic necrosis
- Rare development of exfoliative cutaneous reactions
- Recommended discontinuation if rash develops in patients with fungal infections
- Use not recommended during lactation
Use in Special Populations
- Use in the elderly
- Use in renal impairment, including adjustments based on creatinine clearance
Overdose Effects
- Supportive measures and symptomatic treatment recommended
- Forced volume diuresis to increase elimination rate
- Haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children