Flucon 150 mg (Capsule)

Unit Price: ৳ 22.08 (1 x 10: ৳ 220.80)

Strip Price: ৳ 220.80

Medicine Details

Category	Details
Generic	Fluconazole
Company	Opsonin pharma ltd
Also available as	Flucon 50 mg capsule Flucon 200 mg capsule Flucon 50 mg suspension

Indications

Vaginal Candidiasis
Oropharyngeal Candidiasis
Oesophageal Candidiasis
Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
Kerion
Pityriasis versicolor
Onychomycosis
Invasive candidal infections and cryptococcal infections (including meningitis)
Prevention of cryptococcal meningitis
Prevention of fungal infections in immunocompromised patients
Systemic Candidiasis and Cryptococcal infection
Superficial Candidiasis
Fungal urinary tract infections
Disseminated candidiasis
Prophylaxis for fungal infection in neutropenic cancer patients
Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Triazole antifungal agent, potent inhibitor of fungal cytochrome P-450 dependent enzymes responsible for the synthesis of ergosterol

Dosage & Administration

Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
Children over 1 year:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
Use in Specific Population:
- Elderly patient: Normal dose if no evidence of renal impairment
- Renal Impairment:
  - Creatinine clearance (>41 ml/min): Dosage interval (hours) 24
  - Creatinine clearance (21-40 ml/min): Dosage interval (hours) 48
  - Creatinine clearance (10-20 ml/min): Dosage interval (hours) 72
  - Patients receiving regular dialysis: One dose after every dialysis session
- Children: Renal clearance in children may be proportionately more rapid than in adults, doses up to 12 mg/kg recommended

Interaction

Increased prothombin time after warfarin administration
Prolonged serum half-life of oral sulphonyl ureas
Increased plasma concentrations of fluconazole with co-administration of hydrochlorothiazide
Increase in phenytoin level with co-administration of fluconazole and phenytoin
Pharmacokinetic interaction with combined oral contraceptive
Increase in cyclosporin concentrations with fluconazole use
No clinically significant impairment of fluconazole absorption when co-administered with food, cemetidine, antacids, or following total body irradiation
Decrease in the mean plasma clearance of theophyline with fluconazole administration

Contraindications

Known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

Nausea
Abdominal discomfort
Diarrhoea
Fatulence
Rarely encountered rash
Rare cases of anaphylaxis

Pregnancy & Lactation

Adverse fetal effects seen in animals at dose levels associated with maternal toxicity, should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed

Precautions & Warnings

Abnormalities of hepatic, renal, haematological and other biochemical function tests observed in some patients
Rare cases of hepatic necrosis
Rarely developed exfoliative cutaneous reactions
Not recommended for use during lactation

Use in Special Populations

Elderly: Normal dose recommended if no evidence of renal impairment
Renal Impairment: No adjustments in single dose therapy required, modifications in multiple dose therapy based on creatinine clearance
Haemodialysis: One dose after every dialysis session

Overdose Effects

Supportive measures and symptomatic treatment, forced volume diuresis may increase elimination rate, haemodialysis decreases plasma levels by approximately 50%