Aripen 10 mg (Tablet)

Unit Price: ৳ 5.02 (3 x 10: ৳ 150.60)
Strip Price: ৳ 50.20

Medicine Details

Category Details
Generic Aripiprazole
Company Opsonin pharma ltd
Also available as
Aripen 15 mg tablet

Indications

  • Schizophrenia
  • Bipolar disorder
  • Adjunctive treatment of major depressive disorder
  • Irritability associated with autistic disorder
  • Agitation associated with schizophrenia or bipolar mania

Pharmacology

Atypical antipsychotic; Partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors, antagonist activity at Serotonin 5-HT 2A receptors

Dosage

  • Schizophrenia (adults):
    • Initial Dose: 10-15 mg/day
    • Recommended Dose: 10-15 mg/day
    • Maximum Dose: 30 mg/day
  • Schizophrenia (adolescents):
    • Initial Dose: 2 mg/day
    • Recommended Dose: 10 mg/day
    • Maximum Dose: 30 mg/day
  • Bipolar mania (adults, monotherapy):
    • Initial Dose: 15 mg/day
    • Recommended Dose: 15 mg/day
    • Maximum Dose: 30 mg/day
  • Bipolar mania (adults, adjunct to lithium or valproate):
    • Initial Dose: 10-15 mg/day
    • Recommended Dose: 15 mg/day
    • Maximum Dose: 30 mg/day
  • Bipolar mania (pediatric patients):
    • Initial Dose: 2 mg/day
    • Recommended Dose: 10 mg/day
    • Maximum Dose: 30 mg/day
  • Adjunct to antidepressants for the treatment of major depressive disorder:
    • Initial Dose: 2-5 mg/day
    • Recommended Dose: 5-10 mg/day
    • Maximum Dose: 15 mg/day
  • Irritability associated with autistic disorder (pediatric patients):
    • Initial Dose: 2 mg/day
    • Recommended Dose: 5-10 mg/day
    • Maximum Dose: 15 mg/day

Administration

  • Oral formulations: Administer once daily without regard to meals
  • IM injection: Wait at least 2 hours between doses. Maximum daily dose 30 mg

Interaction

Caution with other centrally acting drugs and alcohol. Carbamazepine could increase clearance, ketoconazole, quinidine, fluoxetine, or paroxetine can inhibit elimination.

Contraindications

Known hypersensitivity to Aripiprazole

Side Effects

  • Vomiting
  • Nausea
  • Akathisia
  • Extrapyramidal disorder
  • Somnolence
  • Sedation
  • Dizziness
  • Insomnia
  • Tremor
  • Restlessness
  • Fatigue
  • Blurred vision
  • Salivary hypersecretion
  • Constipation
  • Pyrexia
  • Drooling
  • Decreased appetite

Pregnancy & Lactation

Pregnancy category C. Avoid during pregnancy. Not recommended for breastfeeding women.

Precautions & Warnings

  • Increased incidence of cerebrovascular adverse events in elderly patients with Dementia-Related Psychosis
  • Increased risk of suicidality in children, adolescents, and adults with major depressive disorder
  • Discontinue if clinically appropriate for Tardive dyskinesia
  • Associated with metabolic changes like hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain
  • Use with caution in patients with known cardiovascular or cerebrovascular disease for Orthostatic hypotension
  • Use cautiously in patients with a history of seizures for Seizures/Convulsions
  • Caution when operating machinery

Overdose Effects

Aripen at doses up to 1080 mg causes no fatalities. Signs and symptoms include nausea, vomiting, asthenia, diarrhea, and somnolence

Therapeutic Class

Atypical neuroleptic drugs

Storage Conditions

Keep below 30°C temperature, away from light and moisture. Keep out of the reach of children

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