Fluconal 50 mg (Tablet)
Unit Price: ৳ 8.07 (2 x 10: ৳ 161.40)
Strip Price: ৳ 80.70
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Triazole antifungal agent, potent inhibitor of fungal cytochrome P-450 dependent enzymes
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
- Children over 1 year:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
- Use in Specific Population:
- Elderly patient: Use normal dose if no evidence of renal impairment
- Renal Impairment: Dosage intervals modified based on creatinine clearance
Interaction
- Increased prothrombin time with warfarin
- Prolonged serum half-life of oral sulphonyl ureas
- Increased plasma concentrations when co-administered with hydrochlorothiazide
- Potential interaction with phenytoin and rifampicin
- Effect on combined oral contraceptives
- Slowly increased cyclosporin concentrations
- No impairment of absorption with food, cimetidine, antacids or total body irradiation
- Decrease in theophylline plasma clearance
Contraindications
Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rarely encountered rash (Incidence less than 1%)
- Rare cases of anaphylaxis
Pregnancy & Lactation
Not recommended for use in pregnancy or in women of childbearing potential unless adequate contraception is employed
Precautions & Warnings
- Abnormalities of hepatic, renal, haematological, and other biochemical function tests observed in some patients with serious underlying diseases
- Rare development of exfoliative cutaneous reactions
- Use of Fluconal is found in human breast milk at concentrations similar to plasma, not recommended during lactation
Overdose Effects
Supportive measures and symptomatic treatment with gastric lavage if necessary, forced volume diuresis may increase elimination rate, haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children