Flucostan 50 mg (Capsule)
Unit Price: ৳ 5.00 (5 x 4: ৳ 100.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Ziska pharmaceuticals ltd |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
Pharmacology
Potent inhibitor of fungal cytochrome P-450 dependent enzymes
Dosage & Administration
- Adults:
- 150 mg as a single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
- 150 mg weekly for 4-6 weeks for Tinea infections
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis versicolor
- 150 mg weekly for 12 months for Onychomycosis
- Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for invasive infections
- Others
- Use in Specific Population:
- Dose adjustments in elderly
- Dose adjustments in renal impairment
Interaction
- Warfarin: Increased prothrombin time
- Sulphonyl ureas: Prolonged serum half-life
- Hydrochlorothiazide: Increased plasma concentrations
- Phenytoin: Increased phenytoin levels
- Rifampicin: Decreased AUC and shorter half-life
- Oral contraceptives: No relevant effects
Contraindications
Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rash
- Anaphylaxis (rare)
Pregnancy & Lactation
Adverse fetal effects seen in animals at high dose levels
Precautions & Warnings
- Abnormalities in hepatic, renal, haematological tests
- Hepatic necrosis in severe underlying disease patients
- Exfoliative cutaneous reactions (rare)
- Discontinue if rash develops
- Avoid use in lactation
- Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Elderly patients: Use normal dose unless evidence of renal impairment
- Renal impairment: Dose adjustments based on creatinine clearance
Overdose Effects
Supportive and symptomatic treatment, gastric lavage if necessary, haemodialysis may decrease plasma levels by 50%
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children