Aripen 15 mg (Tablet)

Unit Price: ৳ 7.03 (2 x 10: ৳ 140.60)
Strip Price: ৳ 70.30

Medicine Details

Category Details
Generic Aripiprazole
Company Opsonin pharma ltd
Also available as
Aripen 10 mg tablet

Indications

  • Schizophrenia
  • Bipolar disorder
  • Adjunctive treatment of major depressive disorder
  • Irritability associated with autistic disorder
  • Agitation associated with schizophrenia or bipolar mania

Pharmacology

Aripiprazole is an atypical antipsychotic with partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors, and antagonist activity at Serotonin 5-HT 2A receptors.

Dosage

  • Schizophrenia - adults:
    • Initial Dose: 10-15 mg/day
    • Recommended Dose: 10-15 mg/day
    • Maximum Dose: 30 mg/day
  • Schizophrenia - adolescents (ages 13-17 years):
    • Initial Dose: 2 mg/day
    • Recommended Dose: 10 mg/day
    • Maximum Dose: 30 mg/day
  • Bipolar mania - adults: monotherapy:
    • Initial Dose: 15 mg/day
    • Recommended Dose: 15 mg/day
    • Maximum Dose: 30 mg/day
  • Bipolar mania - adults: adjunct to lithium or valproate:
    • Initial Dose: 10-15 mg/day
    • Recommended Dose: 15 mg/day
    • Maximum Dose: 30 mg/day
  • Bipolar mania - pediatric patients (ages 10-17 years):
    • Initial Dose: 2 mg/day
    • Recommended Dose: 10 mg/day
    • Maximum Dose: 30 mg/day
  • Adjunct to antidepressants for the treatment of major depressive disorder - adults:
    • Initial Dose: 2-5 mg/day
    • Recommended Dose: 5-10 mg/day
    • Maximum Dose: 15 mg/day
  • Irritability associated with autistic disorder - pediatric patients (ages 6-17 years):
    • Initial Dose: 2 mg/day
    • Recommended Dose: 5-10 mg/day
    • Maximum Dose: 15 mg/day

Administration

Oral formulations should be administered once daily without regard to meals. IM injection should have at least 2 hours between doses, with a maximum daily dose of 30 mg.

Interaction

Caution should be exercised when taken in combination with other centrally acting drugs and alcohol. Interaction with carbamazepine, ketoconazole, quinidine, fluoxetine, or paroxetine should be monitored.

Contraindications

Known hypersensitivity to Aripiprazole.

Side Effects

  • Vomiting
  • Nausea
  • Akathisia
  • Extrapyramidal disorder
  • Somnolence
  • Sedation
  • Dizziness
  • Insomnia
  • Tremor
  • Restlessness
  • Fatigue
  • Blurred vision
  • Salivary hypersecretion
  • Constipation
  • Pyrexia
  • Drooling
  • Decreased appetite

Pregnancy & Lactation

  • Pregnancy: Category C. Should be avoided during pregnancy.
  • Lactation: Not recommended for women receiving Aripiprazole.

Precautions & Warnings

  • Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse events
  • Suicidality & Antidepressants: Increased risk of suicidality
  • Tardive dyskinesia: Discontinue if clinically appropriate
  • Metabolic changes: Associated with hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain
  • Orthostatic hypotension: Use with caution in patients with known cardiovascular or cerebrovascular disease
  • Seizures/Convulsions: Use cautiously in patients with a history of seizures
  • Caution when operating machinery

Overdose Effects

Aripiprazole at doses up to 1080 mg causes no fatalities, but can cause symptoms such as nausea, vomiting, asthenia, diarrhea, and somnolence.

Therapeutic Class

Atypical neuroleptic drugs

Storage Conditions

Keep below 30°C temperature, away from light & moisture, and out of the reach of children.

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