Flukzol 50 mg (Capsule)

Unit Price: ৳ 8.03 (3 x 10: ৳ 240.90)
Strip Price: ৳ 80.30

Medicine Details

Category Details
Generic Fluconazole
Company Sharif pharmaceuticals ltd
Also available as
Flukzol 150 mg capsule

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes responsible for the synthesis of ergosterol.

Dosage & Administration

  • Adults:
    • Vaginal Candidiasis: 150 mg as a single dose
    • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
    • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
    • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
    • Kerion: 50 mg daily for 20 days
    • Pityriasis versicolor: 400 mg as a single dose
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
    • Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
    • Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
  • Pediatric Use: In serious life-threatening infections, doses up to 12 mg/kg daily has been given to children aged 5-13 years

Interaction

  • Warfarin: Fluconazole increased prothrombin time
  • Sulphonylureas: Increased serum half-life
  • Hydrochlorothiazide: Increased plasma concentrations
  • Phenytoin: May increase the level of phenytoin
  • Rifampicin: Resulted in a 25% decrease in the AUC and 20% shorter half-life of fluconazole

Contraindications

Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

  • Nausea
  • Abdominal discomfort
  • Diarrhoea
  • Flatulence
  • Rash
  • Anaphylaxis

Pregnancy & Lactation

Fluconazole adverse fetal effects seen in animals only at dose levels associated with maternal toxicity

Precautions & Warnings

  • Underlying Diseases: Abnormalities of hepatic, renal, hematological, and other biochemical function tests have been observed
  • Hepatic Necrosis: Some patients had post-mortem findings which included hepatic necrosis
  • Cutaneous Reactions: Rarely developed exfoliative cutaneous reactions such as Stevens-Johnson Syndrome and toxic epidermal necrolysis
  • Use During Lactation: Found in human breast milk at concentrations similar to plasma
  • Driving/Use of Machinery: Unlikely to impair a patient's ability

Use in Special Populations

  • Elderly: Normal dose should be used if there is no evidence of renal impairment
  • Renal Impairment: Adjustment in dosage intervals based on creatinine clearance

Overdose Effects

Supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Keep in a dry place away from light and heat

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