Fluma 150 mg (Capsule)

Unit Price: ৳ 20.00 (20's pack: ৳ 400.00)

Medicine Details

Category Details
Generic Fluconazole
Company Modern pharmaceuticals ltd
Also available as

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Superficial Candidiasis
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

  • Triazole antifungal agent
  • Inhibitor of fungal cytochrome P-450 dependent enzymes
  • Potent inhibitor of fungal cell membrane synthesis of ergosterol

Dosage & Administration

  • 150 mg single dose for Vaginal Candidiasis
  • 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
  • 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
  • 150 mg weekly for 4-6 weeks for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • 50 mg daily for 20 days for Kerion
  • 400 mg as a single dose for Pityriasis versicolor
  • 150 mg weekly for 12 months for Onychomycosis
  • Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections (including meningitis)
  • Orally or by IV infusion 200 mg daily for Prevention of cryptococcal meningitis
  • Orally or by IV infusion, 50-400 mg daily for Prevention of fungal infections in immunocompromised patients
  • 1-2 mg/kg daily for Superficial Candidiasis in children over 1 year
  • 3-6 mg/kg daily for Systemic Candidiasis & Cryptococcal infection in children

Interaction

  • Increases prothrombin time after warfarin administration
  • Prolongs the serum half-life of concomitantly administered oral sulphonyl ureas
  • Increases plasma concentrations of fuconazole when co-administered with hydrochlorothiazide
  • Increases the level of phenytoin
  • Results in a decrease in the AUC and shorter half-life when co-administered with rifampicin
  • Affects the AUCs of ethinyl estradiol and levonorgestrel when combined with oral contraceptives
  • Slowly increases cyclosporin concentrations
  • No clinically significant impairment of fuconazole absorption when co-administered with food, cimetidine, antacids or following total body irradiation for bone marrow transplantation
  • Results in a decrease in the mean plasma clearance of theophylline

Contraindications

  • Known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

  • Nausea
  • Abdominal discomfort
  • Diarrhoea
  • Flatulence
  • Rash
  • Anaphylaxis

Pregnancy & Lactation

  • Adverse fetal effects seen in animals at high dose levels
  • Should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed

Precautions & Warnings

  • Abnormalities of hepatic, renal, haematological and other biochemical function tests observed in some patients
  • Rare cases of hepatic necrosis
  • Development of exfoliative cutaneous reactions
  • Not recommended for use during lactation
  • Unlikely to impair a patient's ability to drive or use machinery

Use in Special Populations

  • Normal dose should be used in the elderly
  • Dosage intervals or daily dosage should be adjusted in patients with renal impairment
  • Excreted predominantly in the urine as unchanged drug

Overdose Effects

  • Supportive measures and symptomatic treatment with gastric lavage if necessary
  • Forced volume diuresis may increase the elimination rate
  • Three-hour session of haemodialysis decreases plasma levels by approximately 50%

Therapeutic Class

  • Drugs for subcutaneous and mycoses

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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