Aripra 15 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Aripiprazole |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Schizophrenia
- Bipolar disorder
- Adjunctive treatment of major depressive disorder
- Irritability associated with autistic disorder
- Agitation associated with schizophrenia or bipolar mania
Pharmacology
Aripiprazole is an atypical antipsychotic with partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors and antagonist activity at Serotonin 5-HT 2A receptors.
Dosage
- Schizophrenia (adults):
- Initial Dose: 10-15 mg/day
- Recommended Dose: 10-15 mg/day
- Maximum Dose: 30 mg/day
- Bipolar mania (adults) - monotherapy:
- Initial Dose: 15 mg/day
- Recommended Dose: 15 mg/day
- Maximum Dose: 30 mg/day
- Bipolar mania (pediatric patients):
- Initial Dose: 2 mg/day
- Recommended Dose: 10 mg/day
- Maximum Dose: 30 mg/day
- Major depressive disorder (adults):
- Initial Dose: 2-5 mg/day
- Recommended Dose: 5-10 mg/day
- Maximum Dose: 15 mg/day
Administration
- Oral formulations: Administer once daily without regard to meals
- IM injection: Wait at least 2 hours between doses. Maximum daily dose 30 mg
Interaction
Caution required when taken with other centrally acting drugs and alcohol. Carbamazepine could cause an increase in clearance, while ketoconazole, quinidine, fluoxetine, or paroxetine can inhibit elimination.
Contraindications
Known hypersensitivity to Aripiprazole
Side Effects
- Vomiting
- Nausea
- Akathisia
- Extrapyramidal disorder
- Somnolence
- Sedation
- Dizziness
- Insomnia
- Tremor
- Restlessness
- Fatigue
- Blurred vision
- Salivary hypersecretion
- Constipation
- Pyrexia
- Drooling
- Decreased appetite
Pregnancy & Lactation
Pregnancy category C. Avoid during pregnancy. Not recommended for breastfeeding women.
Precautions & Warnings
- Increased incidence of cerebrovascular adverse events in elderly patients with dementia-related psychosis
- Increased risk of suicidality when used with antidepressants
- Discontinue if tardive dyskinesia clinically appropriate
- Associated with metabolic changes, orthostatic hypotension, seizures/convulsions
- Use caution when operating machinery
Overdose Effects
Aripra at doses up to 1080 mg causes no fatalities. Signs and symptoms observed with overdose included nausea, vomiting, asthenia, diarrhea, and somnolence
Therapeutic Class
Atypical neuroleptic drugs
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children