Flunac 50 mg/5 ml (Powder for Suspension)

35 ml bottle: ৳ 78.00

Medicine Details

Category Details
Generic Fluconazole
Company Drug international ltd
Also available as
Flunac 50 mg capsule Flunac 150 mg capsule

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Superficial Candidiasis
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Fluconazole is a triazole antifungal agent and a potent inhibitor of fungal cytochrome P-450 dependent enzymes.

Dosage & Administration

  • Adults:
    • 150 mg single dose for Vaginal Candidiasis
    • 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
    • 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
    • 150 mg weekly for 4-6 weeks for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
    • 50 mg daily for 20 days for Kerion
    • 400 mg as a single dose for Pityriasis versicolor
    • 150 mg weekly for 12 months for Onychomycosis
    • Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections (including meningitis)
    • Orally or by IV infusion, 200 mg daily for Prevention of cryptococcal meningitis
    • Orally or by IV infusion, 50-400 mg daily for Prevention of fungal infections in immunocompromised patients
  • Children over 1 year:
    • 1-2 mg/kg daily for Superficial Candidiasis
    • 3-6 mg/kg daily for Systemic Candidiasis & Cryptococcal infection
  • Use in Specific Population:
    • Normal dose for Elderly patient if no evidence of renal impairment
    • No adjustment in single dose therapy for Renal Impairment
    • Dosage intervals or daily dosage modification in Renal Impairment based on Creatinine clearance

Interaction

  • Increase in prothrombin time after warfarin administration
  • Prolonged serum half-life of concomitantly administered oral sulphonylureas
  • Increased plasma concentrations of fuconazole by 40% when co-administered with hydrochlorothiazide, resulting in no change in fuconazole dose regimen
  • Increased level of phenytoin and decrease in AUC and half-life of fuconazole when co-administered with phenytoin and rifampicin respectively
  • No clinically significant impairment of fuconazole absorption when co-administered with food, cimetidine, antacids, or following total body irradiation for bone marrow transplantation
  • 18% decrease in the mean plasma clearance of theophylline when administered with fuconazole 200mg for 14 days

Contraindications

Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

  • Nausea
  • Abdominal discomfort
  • Diarrhoea
  • Flatulence
  • Rash (Incidence less than 1%)
  • Rare cases of anaphylaxis

Pregnancy & Lactation

Fluconazole adverse fetal effects seen in animals only at dose levels associated with maternal toxicity, hence not recommended in pregnancy or in women of childbearing potential unless adequate contraception is employed

Precautions & Warnings

  • Abnormalities of hepatic, renal, haematological and other biochemical function tests observed in some patients, particularly those with serious underlying diseases
  • Rare occurrence of hepatic necrosis in patients with severe underlying disease and multiple concomitant medications
  • Rare development of exfoliative cutaneous reactions such as Stevens Johnson Syndrome and toxic epidermal necrolysis, particularly in AIDS patients
  • Use during lactation not recommended as Flunac is found in breast milk at concentrations similar to plasma

Use in Special Populations

  • Recommended dosage based on evidence of renal impairment in elderly patients and patients with creatinine clearance less than 40 ml/min

Overdose Effects

Supportive measures and symptomatic treatment with gastric lavage may be adequate, and forced volume diuresis would probably increase the elimination rate

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Keep in a dry place away from light and heat, and keep out of the reach of children

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