Flunapen 150 mg (Capsule)

Unit Price: ৳ 22.07 (1 x 10: ৳ 220.70)
Strip Price: ৳ 220.70

Medicine Details

Category Details
Generic Fluconazole
Company Concord pharmaceuticals ltd
Also available as

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Superficial Candidiasis
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is essential component of fungal cell membrane which is responsible for the synthesis of ergosterol.

Dosage & Administration

  • Vaginal Candidiasis: 150 mg as a single dose
  • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
  • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
  • Kerion: 50 mg daily for 20 days
  • Pityriasis versicolor: 400 mg as a single dose
  • Onychomycosis: 150 mg weekly for 12 months
  • Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
  • Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
  • Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily

Interaction

In an interaction study, fluconazole increased the prothrombin time after warfarin administration in healthy males

Contraindications

Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

Fluconazole is generally well tolerated. The commonest side effects include symptoms associated with the gastrointestinal tract; these include nausea, abdominal discomfort, diarrhea and flatulence

Pregnancy & Lactation

Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity. Its use in pregnancy or in women of childbearing potential unless adequate contraception is employed

Precautions & Warnings

In some patients, particularly those with serious underlying diseases such as AIDS and cancer, abnormalities of hepatic, renal, hematological and other biochemical function tests have been observed during treatment with fluconazole

Use in Special Populations

Use in the elderly: The normal dose should be used if there is no evidence of renal impairment.

Overdose Effects

In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. As fluconazole is excreted largely in the urine, forced volume diuresis would probably increase the elimination rate.

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