Flunazol 50 mg/5 ml (Powder for Suspension)

35 ml bottle: ৳ 75.00

Medicine Details

Category	Details
Generic	Fluconazole
Company	Pharmadesh laboratories ltd
Also available as	Flunazol 50 mg capsule Flunazol 150 mg capsule

Indications

Vaginal Candidiasis
Oropharyngeal Candidiasis
Oesophageal Candidiasis
Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
Kerion
Pityriasis versicolor
Onychomycosis
Invasive candidal infections and cryptococcal infections (including meningitis)
Prevention of cryptococcal meningitis
Prevention of fungal infections in immunocompromised patients
Systemic Candidiasis and Cryptococcal infection
Superficial Candidiasis
Fungal urinary tract infections
Disseminated candidiasis
Prophylaxis for fungal infection in neutropenic cancer patients
Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Potent inhibitor of fungal cytochrome P-450 dependent enzymes

Dosage & Administration

Adults:
- 150 mg as a single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
- 150 mg weekly for 4-6 weeks for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis versicolor
- 150 mg weekly for 12 months for Onychomycosis
- Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections (including meningitis)
- Orally or by IV infusion 200 mg daily for Prevention of cryptococcal meningitis
- Orally or by IV infusion, 50-400 mg daily for Prevention of fungal infections in immunocompromised patients
Children over 1 year:
- 1-2 mg/kg daily for Superficial Candidiasis
- 3-6 mg/kg daily for Systemic Candidiasis & Cryptococcal infection
- Up to 12 mg/kg daily for serious life-threatening infections (5-13 years)
Use in Specific Population: Dose adjustment based on creatinine clearance for renal impairment

Interaction

May increase prothrombin time after warfarin administration
Prolongs the serum half-life of concomitantly administed oral sulphonyl ureas
Co-administration with hydrochlorothiazide increases plasma concentrations
May increase the level of phenytoin
Results in a decrease in AUC and shorter half-life when co-administered with rifampicin
No relevant effects on hormone levels in a certain dosage range of combined oral contraceptive
Slowly increases cyclosporin concentrations
No clinically significant impairment of absorption when co-administered with food, cimetidine, antacids, or following total body irradiation for bone marrow transplantation
Results in a decrease in the mean plasma clearance of theophylline

Contraindications

Hypersensitivity to Fluconazole or related triazole compounds

Side Effects

Nausea, abdominal discomfort, diarrhea, flatulence, rash, rare cases of anaphylaxis

Pregnancy & Lactation

Not recommended for use unless adequate contraception is employed

Precautions & Warnings

Abnormalities of hepatic, renal, hematological, and biochemical function tests observed in some patients with serious underlying diseases
Rare cases of hepatic necrosis
Rare development of exfoliative cutaneous reactions, more prone in AIDS patients
Not recommended for use during lactation
Unlikely to impair a patient's ability to drive or use machinery

Use in Special Populations

Elderly: Normal dose if no evidence of renal impairment, dosage adjustment for renal impairment
Renal Impairment: Dose adjustment based on creatinine clearance

Overdose Effects

Supportive measures and symptomatic treatment, forced volume diuresis may increase elimination rate, haemodialysis decreases plasma levels by approximately 50%