Flutinex 150 mg (Capsule)
Unit Price: ৳ 22.06 (3 x 4: ৳ 264.72)
Strip Price: ৳ 88.24
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Novatek pharmaceuticals ltd |
| Also available as |
Title
- Flutinex
Categories
- Antifungal
- Medication
- Pharmaceutical
Description
- Flutinex is a triazole antifungal agent indicated for various fungal infections including vaginal candidiasis, oropharyngeal candidiasis, tinea infections, onychomycosis, and cryptococcal infections.
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Tinea Infections
- Kerion
- Onychomycosis
- Cryptococcal Infections
- Pityriasis Versicolor
- Invasive Candidal Infections
- Prevention of Cryptococcal Meningitis
- Fungal Urinary Tract Infections
- Disseminated Candidiasis
- Prophylaxis for Fungal Infection in Neutropenic Cancer Patients
- Acute Treatment of Other Systemic Fungal Infections
Pharmacology
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol in fungal cell membrane
Dosage & Administration
- 150 mg single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
- 150 mg weekly for 4-6 weeks for Tinea Infections
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis Versicolor
- 150 mg weekly for 12 months for Onychomycosis
- Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for Cryptococcal Infections
- Orally or by IV infusion 200 mg daily for Prevention of Cryptococcal Meningitis
- Orally or by IV infusion, 50-400 mg daily for Prevention of Fungal Infections in Immunocompromised Patients
Interaction
- Increased prothrombin time after warfarin administration
- Prolonged serum half-life of oral sulphonylureas
- Increased plasma concentrations when co-administered with hydrochlorothiazide
- Potential increase in phenytoin levels
- Potential decrease in fluconazole AUC and shorter half-life when co-administered with rifampicin
Contraindications
- Hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhea
- Flatulence
- Rash
- Anaphylaxis (rare)
Pregnancy & Lactation
- Adverse fetal effects seen in animals at high doses
- Not recommended for use in pregnancy or lactation unless with adequate contraception
Precautions & Warnings
- Abnormalities in hepatic, renal, haematological and biochemical function tests observed
- Rare cases of severe cutaneous reactions
- Use not recommended during lactation
- Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Normal dose recommended for elderly with no evidence of renal impairment
- Excreted predominantly in urine, dosage adjustments required for renal impairment
Overdose Effects
- Supportive and symptomatic treatment indicated
- Forced volume diuresis may increase elimination rate
- Haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
- Drugs for Subcutaneous and Mycoses
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children