Fluzole 150 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Globe pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis
- Tinea cruris
- Tinea pedis
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections
- Cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Fluconazole is a triazole antifungal agent and a potent inhibitor of fungal cytochrome P-450 dependent enzymes.
Dosage and administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Children:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
- Specific population:
- Elderly patient: The normal dose should be used if there is no evidence of renal impairment
- Renal impairment: Dosing intervals and amounts to be modified based on creatinine clearance
Interaction
Fluconazole interacts with several medications including anticoagulants, oral sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, theophylline, and others.
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds.
Side effects
Common side effects include gastrointestinal symptoms, while rare cases of rash and anaphylaxis have been reported.
Pregnancy and lactation
Fluconazole should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed.
Precautions and warnings
Abnormalities of hepatic, renal, hematological, and other biochemical function tests have been observed in some patients during treatment with fluconazole. Exfoliative cutaneous reactions, hepatic necrosis, and severe cutaneous reactions have been reported rarely.
Use in special populations
- Elderly: The normal dose should be used if there is no evidence of renal impairment
- Renal impairment: Dosing intervals or daily dosage should be adjusted based on creatinine clearance
Overdose effects
Supportive measures and symptomatic treatment with gastric lavage may be adequate in the event of overdosage. Forced volume diuresis and haemodialysis may be considered.
Therapeutic class
Drugs for subcutaneous and mycoses
Storage conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.