Funzole 150 mg (Capsule)

Unit Price: ৳ 22.00 (12's pack: ৳ 264.00)

Medicine Details

Category Details
Generic Fluconazole
Company Monicopharma ltd
Also available as
Funzole 50 mg capsule Funzole 50 mg suspension

Title

  • Funzole

Categories

  • Medicine
  • Antifungal
  • Medication

Description

  • Funzole is a triazole antifungal agent used to treat various fungal infections including vaginal candidiasis, oropharyngeal candidiasis, esophageal candidiasis, tinea corporis, tinea cruris, tinea pedis, kerion, pityriasis versicolor, onychomycosis, invasive candidal infections, cryptococcal infections, prevention of cryptococcal meningitis, prevention of fungal infections in immunocompromised patients, systemic candidiasis, fungal urinary tract infections, disseminated candidiasis, prophylaxis for fungal infection in neutropenic cancer patients, and acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis.

Dimensions

N/A

Color options

N/A

Functions

  • Antifungal agent
  • Inhibitor of fungal cytochrome P-450 dependent enzymes

Materials

N/A

Technical specifications

  • Adults:
    • Vaginal Candidiasis: 150 mg as a single dose
    • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
    • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
    • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
    • Kerion: 50 mg daily for 20 days
    • Pityriasis versicolor: 400 mg as a single dose
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
    • Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
    • Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
  • Children over 1 year:
    • In Superficial Candidiasis: 1-2 mg/kg daily
    • In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
  • Use in Specific Population:
    • Elderly patient: The normal dose should be used if there is no evidence of renal impairment
    • Renal Impairment: No adjustment in single dose therapy is required. In multiple dose therapy of patients with renal impairment, normal doses should be given on days 1 and 2 of treatment and thereafter the dosage intervals should be modified based on the creatinine clearance.

Design elements

N/A

Usability features

N/A

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis
  • Tinea cruris
  • Tinea pedis
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections
  • Cryptococcal infections
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Fluconazole is a potent inhibitor of fungal cytochrome P-450 dependent enzymes and is a triazole antifungal agent.

Interaction

  • May increase prothrombin time after warfarin administration
  • May prolong the serum half-life of oral sulphonylureas
  • Co-administration with hydrochlorothiazide may increase plasma concentrations of fluconazole
  • May increase the level of phenytoin
  • May decrease the AUC and shorten half-life when co-administered with rifampicin
  • May affect the AUCs of ethinyl estradiol and levonorgestrel when co-administered with combined oral contraceptives
  • May slowly increase cyclosporine concentrations in renal transplant patients
  • Absorption is not impaired when co-administered with food, cimetidine, antacids, or following total body irradiation for bone marrow transplantation
  • May decrease the mean plasma clearance of theophylline

Contraindications

  • Known hypersensitivity to fluconazole or related triazole compounds

Side effects

  • Nausea
  • Abdominal discomfort
  • Diarrhea
  • Flatulence
  • Rash (rare)
  • Anaphylaxis (rare)

Pregnancy and lactation

Should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed

Precautions and warnings

  • Abnormalities of hepatic, renal, hematological, and other biochemical function tests have been observed in some patients
  • Severe underlying diseases such as AIDS and cancer may result in abnormalities during treatment
  • Rare cases of hepatic necrosis and exfoliative cutaneous reactions reported
  • Use during lactation is not recommended
  • Unlikely to impair a patient's ability to drive or use machinery

Use in special populations

  • Elderly: The normal dose should be used if there is no evidence of renal impairment
  • Renal Impairment: Dosage intervals or daily dosage should be modified based on creatinine clearance

Overdose effects

Supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. Forced volume diuresis may increase the elimination rate. Haemodialysis decreases plasma levels by approximately 50%

Therapeutic class

  • Drugs for subcutaneous and mycoses

Storage conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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