F-Zol 50 mg/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis
- Tinea cruris
- Tinea pedis
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections
- Cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of systemic fungal infections
- Histoplasmosis
- Coccidioidomycosis
Pharmacology
Potent inhibitor of fungal cytochrome P-450 dependent enzymes
Dosage & Administration
- Adults:
- 150 mg single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for Oesophageal Candidiasis
- 150 mg weekly for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis versicolor
- 150 mg weekly for 12 months for Onychomycosis
- Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections
- 200 mg daily for Prevention of cryptococcal meningitis
- 50-400 mg daily for Prevention of fungal infections in immunocompromised patients
- Children over 1 year:
- 1-2 mg/kg daily for Superficial Candidiasis
- 3-6 mg/kg daily for Systemic Candidiasis & Cryptococcal infection
- Use in Specific Population:
- Elderly patient: Normal dose if no evidence of renal impairment
- Renal Impairment: Dosage intervals modified based on creatinine clearance
Interaction
Interacts with warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, theophyline, cemetidine, antacids, and food
Contraindications
Hypersensitivity to Fluconazole or related triazole compounds
Side Effects
Nausea, abdominal discomfort, diarrhoea, fatulence, rash, anaphylaxis
Pregnancy & Lactation
Not recommended for use in pregnancy or in women of childbearing potential unless adequate contraception is employed
Precautions & Warnings
Abnormalities of hepatic, renal, haematological and other biochemical function tests observed in some patients, hepatic necrosis, exfoliative cutaneous reactions, caution in lactation, therapy unlikely to impair driving or use of machinery
Use in Special Populations
- Elderly: Normal dose if no evidence of renal impairment
- Renal Impairment: Dosage intervals or daily dosage adjusted based on creatinine clearance
Overdose Effects
Supportive measures, symptomatic treatment, forced volume diuresis, haemodialysis
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Dry place, away from light and heat, out of reach of children